Oncotarget

Research Papers:

Genetic variation and forensic characteristic analysis of 25 STRs of a novel fluorescence co-amplification system in Chinese Southern Shaanxi Han population

Yao-Shun Liu, Jian-Gang Chen, Ting Mei, Yu-Xin Guo, Hao-Tian Meng, Jian-Fei Li, Yuan-Yuan Wei, Xiao-Ye Jin, Bo-Feng Zhu and Li-Ping Zhang _

PDF  |  HTML  |  Supplementary Files  |  How to cite

Oncotarget. 2017; 8:55443-55452. https://doi.org/10.18632/oncotarget.19317

Metrics: PDF 1349 views  |   HTML 3218 views  |   ?  


Abstract

Yao-Shun Liu1,2,3,4,*, Jian-Gang Chen1,6,*, Ting Mei1,2,3, Yu-Xin Guo2,3, Hao-Tian Meng2,3, Jian-Fei Li5, Yuan-Yuan Wei2,3, Xiao-Ye Jin2,3, Bo-Feng Zhu2,3,4,** and Li-Ping Zhang1,**

1Department of Biochemistry and Molecular Biology, Basic Medicine College of Xinjiang Medical University, Urumqi, Xinjiang 830011, P. R. China

2Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi'an, Shaanxi 710004, P. R. China

3Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi 710004, P. R. China

4Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P. R. China

5School of Marxism, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, P.R. China

6Science and Technology Institute, Xinjiang Public Security Department, Urumqi, Xinjiang 830006, P.R. China

*The first two authors were equal to this article

**These authors have contributed equally to this work and were co-corresponding authors

Correspondance to:

Li-Ping Zhang, email: [email protected]

Keywords: genetic polymorphisms, Southern Shaanxi Han population, forensic characteristic analysis, autosomal STR, Y-STR

Received: April 15, 2017     Accepted: June 05, 2017     Published: July 18, 2017

ABSTRACT

We analyzed the genetic polymorphisms of 15 autosomal and 10 Y-chromosomal STR loci in 214 individuals of Han population from Southern Shaanxi of China and studied the genetic relationships between Southern Shaanxi Han and other populations. We observed a total of 150 alleles at 15 autosomal STR loci with the corresponding allelic frequencies ranging from 0.0023 to 0.5210, and the combined power of discrimination and exclusion for the 15 autosomal STR loci were 0.99999999999999998866 and 0.999998491, respectively. For the 10 Y-STR loci, totally 100 different haplotypes were obtained, of which 94 were unique. The discriminatory capacity and haplotype diversity values of the 10 Y-STR loci were 0.9259 and 0.998269, respectively. The results demonstrated high genetic diversities of the 25 STR loci in the population for forensic applications. We constructed neighbor-joining tree and conducted principal component analysis based on 15 autosomal STR loci and conducted multidimensional scaling analysis and constructed neighbor-joining tree based on 10 Y-STR loci. The results of population genetic analyses based on both autosomal and Y-chromosome STRs indicated that the studied Southern Shaanxi Han population had relatively closer genetic relationship with Eastern Han population, and distant relationships with Croatian, Serbian and Moroccan populations.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 19317