Oncotarget

Research Papers:

The prognostic impacts of TEA domain (TEAD) transcription factor polymorphisms in Chinese hepatocellular carcinoma patients

Haiyan Xia, Juan Wen, Weiyong Zhao, Dongying Gu, Zhibin Hu, Jinfei Chen and Zhi Xu _

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Oncotarget. 2017; 8:69823-69832. https://doi.org/10.18632/oncotarget.19310

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Abstract

Haiyan Xia1,*, Juan Wen2,3,*, Weiyong Zhao4,*, Dongying Gu1, Zhibin Hu3,5, Jinfei Chen1 and Zhi Xu1

1Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China

2Nanjing Maternity and Child Health Care Institute, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, China

3Department of Epidemiology and Biostatistics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, Nanjing, China

4Department of Radiation Oncology, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China

5State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China

*These authors have contributed equally to this work

Correspondence to:

Zhi Xu, email: [email protected]

Keywords: TEA domain family member, single nucleotide polymorphism, hepatocellular carcinoma, prognosis

Received: March 23, 2017     Accepted: June 20, 2017     Published: July 17, 2017

ABSTRACT

TEA domain (TEAD) transcription factors play an important role in hepatocellular carcinoma (HCC) development and progression by regulating the expression of a number of genes. However, the association of their genetic variations with HCC prognosis remains elusive. Seven potentially functional single nucleotide polymorphisms in TEAD1-4 (rs2304733, rs10831923, rs12104362, rs3745305, rs11756089, rs2076173, rs7135838) were genotyped from 331 hepatitis B virus positive HCC patients using the Sequenom MassARRAY iPLEX platform. The TEAD3 rs2076173 C allele and rs11756089 T allele were identified as protective alleles as they were significantly associated with longer median overall survival time (MST). The T allele of rs2076173 was significantly associated with HCC survival independent of age, gender, smoking and drinking status, BCLC stage, and chemotherapy or TACE status (HR = 0.73, 95% CI = 0.56-0.93, P = 0.012). This protective effect was more prominent for patients who were non-drinkers (P for multiplicative interaction = 0.002). Patients had more than one of these protective alleles had significant longer MST of 19.25 months than those had none (MST=12.85 months, adjusted HR = 0.56, 95% CI = 0.33-0.95, P=0.030), especially for those non-drinkers (adjusted HR = 0.48, 95% CI = 0.32-0.74, P = 0.001). These findings suggested that rs2076173 and rs11756089 in TEAD3 gene could serve as genetic markers for favorable survival in the Chinese HCC patients.


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