Intensity-modulated radiotherapy for hepatocellular carcinoma: dosimetric and clinical results

Sun Hyun Bae, Won Il Jang and Hee Chul Park _

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Oncotarget. 2017; 8:59965-59976. https://doi.org/10.18632/oncotarget.19219

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Sun Hyun Bae1,*, Won Il Jang2,* and Hee Chul Park3,4

1Department of Radiation Oncology, Soonchunhyang University College of Medicine, Bucheon, Korea

2Department of Radiation Oncology, Korea Institute of Radiological and Medical Sciences, Seoul, Korea

3Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

4Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University, Seoul, Korea

*These authors contributed equally to this work

Correspondence to:

Hee Chul Park, email: [email protected]

Keywords: conformal radiotherapy, hepatocellular carcinoma, intensity-modulated radiotherapy, radiotherapy

Received: January 23, 2017     Accepted: June 02, 2017     Published: July 13, 2017


Since the introduction of 3-dimensional conformal radiotherapy (3DCRT), new radiotherapy techniques have expanded the indication of radiotherapy for the treatment of hepatocellular carcinoma (HCC), from the hitherto palliative to a now curative-intent purpose. Intensity-modulated radiotherapy (IMRT), currently the most advanced radiotherapy technique, is considered an attractive option for the treatment of HCC, and is more widely applied because it can deliver a higher dose to the tumor than 3DCRT while sparing surrounding normal organs. However, the advantages and potential disadvantages of IMRT for treating HCC have not been fully established. This article deals with three different IMRT techniques, including static IMRT and volumetric modulated arc therapy using conventional multileaf collimator (MLC) mounted linear accelerators, and helical IMRT using binary MLC mounted helical tomotherapy machine. We review dosimetric and clinical studies for these IMRT techniques for the treatment of HCC.

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