Clinical Research Papers:
Influence of body mass index on postoperative complications after thymectomy in myasthenia gravis patients
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Xu-Dong Liu1,2, Ming-Rui Shao1, Lei Sun1, Lin Zhang1, Xin-Shan Jia3,4 and Wen-Ya Li1
1Department of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
2Department of Rheumatology and Immunology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
3Department of Pathology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
4Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning Province, China
Wen-Ya Li, email: email@example.com
Keywords: myasthenia gravis, body mass index, postoperative complications, thymectomy
Abbreviations: ANOVA: analysis of variance; BMI: body mass index; MG: Myasthenia gravis; PRF: postoperative respiratory failure; ROC: receiver operating characteristic
Received: February 14, 2017 Accepted: June 10, 2017 Published: July 12, 2017
Objectives: It is not clear whether being overweight or obese influences postoperative complications in myasthenia gravis (MG) patients. We retrospectively investigated an association between body mass index (BMI) and postoperative complications in MG.
Materials and Methods: Fifty-nine MG patients who had undergone transsternal thymectomy were classified as low or high BMI based on the criteria for Asian-Pacific populations. An association between BMI and complications was analyzed.
Results: MG patients with high BMI had significantly higher rates of major adverse complications (P = 0.033), postoperative respiratory failure (P = 0.045), and longer postoperative hospitalization (P = 0.005). The optimal cutoff value of BMI for postoperative respiratory failure was 23.3 kg/m2, with a sensitivity of 75.0% and a specificity of 64.7% (P = 0.046).
Conclusions: MG patients with a BMI indicating overweight or obesity have a higher risk of postoperative complications after thymectomy. Thus, close monitoring must be performed when surgery is necessary.
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