Alcohol consumption and gastric cancer risk: a meta-analysis of prospective cohort studies

Xue Han _, Li Xiao, Yao Yu, Yu Chen and Hai-Hua Shu

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Oncotarget. 2017; 8:83237-83245. https://doi.org/10.18632/oncotarget.19177

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Xue Han1,*, Li Xiao2,*, Yao Yu3, Yu Chen2 and Hai-Hua Shu1

1Department of Anesthesiology, Guangdong Second Provincial General Hospital, Guangzhou, China

2Department of Anesthesiology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

3Department of Anesthesiology, Second Affiliated Hospital of Dalian Medical University, Dalian, China

*These authors contributed equally to this work

Correspondence to:

Xue Han, email: [email protected]

Keywords: alcohol consumption, meta-analysis, gastric cancer, dose-risk relation

Received: March 02, 2017     Accepted: June 30, 2017     Published: July 12, 2017


We performed this meta-analysis to explore the precise quantification relationship between alcohol consumption and gastric cancer and to provide evidence for preventing gastric cancer. We searched PubMed, Embase, and Web of Science for articles published up to December 2016, and identified 23 cohort studies that included a total population of 5,886,792 subjects. We derived meta-analytic estimates using random-effects models, taking into account correlations between estimates. We also investigated the dose–response relationship between gastric cancer risk and alcohol consumption. We found that alcohol consumption increased gastric cancer risk, where the summary risk ratio was 1.17 (95% confidence interval (CI): 1.00–1.34; I2 = 79.6%, p < 0.05. The dose–response analysis showed that every 10 g/d increment in alcohol consumption was associated with 7% increased gastric cancer risk (95% CI 1.02–1.12; I2 = 28.9%, p = 0.002). This meta-analysis provides evidence that alcohol consumption is an important risk factor of the incidence of gastric cancer.

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