Prognostic value of the long noncoding RNA HOTTIP in human cancers

Wei Li, Na Li, Xinmei Kang, Ke Shi and Qiong Chen _

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Oncotarget. 2017; 8:59563-59569. https://doi.org/10.18632/oncotarget.19166

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Wei Li1, Na Li2, Xinmei Kang1, Ke Shi1 and Qiong Chen1

1Department of Geriatrics, Xiangya Hospital of Central South University, Changsha, Hunan Province, People’s Republic of China

2Department of Pathology, The First Affiliated Hospital of Hunan University of Medicine, Huaihua, Hunan Province, People’s Republic of China

Correspondence to:

Qiong Chen, email: [email protected]

Ke Shi, email: [email protected]

Keywords: HOTTIP, lncRNA, cancer, clinical outcome, meta-analysis

Received: March 28, 2017     Accepted: June 28, 2017     Published: July 11, 2017


Human Homeobox A transcript at the distal tip (HOTTIP) is a putative oncogene in solid tumors. We performed a meta-analysis to investigate the association between HOTTIP expression and clinical outcomes in cancer patients. Eligible studies were collected from a literature search of the online electronic databases of Embase, Web of Science, PubMed and the China National Knowledge Infrastructure (up to January 2, 2017). Fixed-effects models were used to compute pooled odds ratios (ORs) and hazard ratios (HRs). In total, we analyzed nine studies that included 800 patients with seven tumor types. Overall survival was lower for patients with high HOTTIP expression than for those with low expression (HR = 2.30, 95% confidence interval [CI]: 1.81–2.91, P < 0.001). High HOTTIP expression was also associated with lymph node metastasis (OR = 2.40, 95% CI: 1.70–3.37, P < 0.001), distant metastasis (OR = 3.30, 95% CI: 1.78–6.12, P < 0.001), poor tumor differentiation (OR = 1.55, 95% CI: 1.03–2.32, P = 0.036) and a poor clinical stage (OR = 3.28, 95% CI: 2.22–4.83, P < 0.001). This meta-analysis demonstrated that high HOTTIP expression in cancer patients is associated with poor clinical outcomes. Thus, HOTTIP is a potential predictive biomarker of cancer.

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