Research Papers:

Clinical study on the relationship between hepatitis B virus infection and risk of breast cancer: a large sized case-control and single center study in southwest of China

Lin-Jie Lu, Vishnu Prasad Adhikari, Chun-Xia Zhao, He Wu, Wei Dai, Xin Li, Hong-Yuan Li, Guo-Sheng Ren, Kai-Nan Wu and Ling-Quan Kong _

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Oncotarget. 2017; 8:72044-72053. https://doi.org/10.18632/oncotarget.19132

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Lin-Jie Lu1,2,*, Vishnu Prasad Adhikari1,*, Chun-Xia Zhao1,*, He Wu1,*, Wei Dai1,*, Xin Li1, Hong-Yuan Li1, Guo-Sheng Ren1, Kai-Nan Wu1 and Ling-Quan Kong1

1Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

2Department of Thyroid and Breast Surgery, Liuzhou People’s Hospital, Liuzhou 545006, China

*These authors have contributed equally to this work

Correspondence to:

Ling-Quan Kong, email: [email protected]

Keywords: breast cancer, hepatitis B virus, risk factor, etiology, breast oncohepatology

Received: August 27, 2016    Accepted: June 04, 2017    Published: July 10, 2017


Purpose: Chronic hepatitis C virus (HCV) infection is reported to be associated with early-onset breast cancer, while, as a hepadnavirus, hepatitis B virus(HBV) infection is more common than HCV in China. In this article, it is aimed to study the relationship between HBV infection and risk of breast cancer in China.

Methods: The clinical data of 2452 cases of initially diagnosed breast cancer and 1926 cases of benign breast disease (as controls) with the consecutive reports of HBV serological markers and liver function tests, available in the Electronic Medical Records of the Breast Cancer Center of Chongqing, the southwest of China, from January 2011 to March 2015, were collected for analysis.

Results: The average age of the initially diagnosed breast cancer patients was 50.3±11.3 years with the age peaking about 40- 49yeaers (39.7%). The positive rate (8.2%) of hepatitis B surface antigen in breast cancer patients was relatively higher than that (7.8%) in controls (P>0.05). While, the positive rate (66.4%)of hepatitis B core antibody in breast cancer patients was significantly higher than that (53.7%) in controls (P<0.05), so were the similar results in the age groups of 40-49 years, after multiple layer analysis stratified by age and compare HBV markers adjusting age with binary logistic regression. Meanwhile, the status of albumin, aminotransferase and aspartate transaminase (41.4 g/L, 22.9 U/L, 22.0 U/L) in breast cancer patients were significantly poorer than those (44.1 g/L,16.8 U/L, 19.2 U/L) in controls (P<0.05).

Conclusions: Exposure to HBV infection may be a risk factor for breast cancer and may be also related to the earlier age onset of breast cancer (peaked around 40-49 years) among Chinese females.

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