Clinical Research Papers:

Assessing right ventricular function in pulmonary hypertension patients and the correlation with the New York Heart Association (NYHA) classification

Xiaoke Shang, Shuna Xiao, Nianguo Dong, Rong Lu _, Lijun Wang, Bin Wang, Yousan Chen, Liang Zhong and Mei Liu

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Oncotarget. 2017; 8:90421-90429. https://doi.org/10.18632/oncotarget.19026

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Xiaoke Shang1,*, Shuna Xiao2,*, Nianguo Dong1, Rong Lu3, Lijun Wang4, Bin Wang1, Yousan Chen5, Liang Zhong6,7 and Mei Liu3

1Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province 430222, China

2Department of Pediatric Intensive Care Unit, Hubei Maternal and Child Health Hospital, Hubei Province 430070, China

3Department of Intensive Care Unit, Wuhan No.1 Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province 430222, China

4Department of Intervention, Wuhan Asia Heart Hospital, Hubei Province 430022, China

5Department of Radiology, Wuhan General Hospital of CPLA, Guangzhou Military Command, Hubei Province 430070, China

6National Heart Centre Singapore, 169609, Singapore

7Duke NUS Medical School, 169857, Singapore

*These authors contributed equally to this work

Correspondence to:

Rong Lu, email: [email protected]

Keywords: right ventricular, pulmonary hypertension (PH), New York Heart Association (NYHA), PV Loop

Received: February 23, 2017     Accepted: June 17, 2017     Published: July 05, 2017


This investigation aimed to compare the pressure-volume loop (PV loop) measurements in three less symptomatic categories (New York Heart Association classes , NYHA I, II, and III) of pulmonary hypertension (PH) patients since NYHA classification system performance is limited by the shortcomings discussed above.

Thirty-six patients were enrolled in this study with PV loop measurement acquisition via micro-conductance catheters. Functional classification according to NYHA was determined with comprehensive assessing function and activity. Catheterization and MRI was applied to obtain variables on right ventricle (RV) functions. Correlation test was applied to test the relationship between measured PV loop measurements and NYHA classification.

A group of PV loop measurements, including end-systolic pressure (RVESP) RV end-diastolic pressure (RVEDP), and RV arterial elastance (RVEa), are well correlated with three NYHA classes (I, II, and III). Moreover, RVESP and RVEa significantly correlated with two groups of NYHA classes (I and II/III) while RVEDP, RV end-diastolic volume (RVEDV), and RV end-systolic volume (RVESV) significantly moderately correlated with two groups of NYHA classes (I/II and III). This study suggests the promising role of PV loop analysis in assessing functional capacity in progressive but less symptomatic PH patients.

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