Oncotarget

Research Papers:

The association between renal sinus fat area and the progression-free survival in Chinese non-metastatic clear-cell renal cell carcinoma patients

Haichao Huang, Shi Chen, Wei Yu, Zirong Ye, Wei Li, Jinchun Xing _ and Xiurong Wu

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Oncotarget. 2017; 8:65481-65491. https://doi.org/10.18632/oncotarget.19012

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Abstract

Haichao Huang1,*, Shi Chen2,*, Wei Yu3, Zirong Ye4, Wei Li1, Jinchun Xing1 and Xiurong Wu2

1Department of Urology, The First Affiliated Hospital of Xiamen University, Siming District, Xiamen, Fujian 361003, China

2Department of Radiology, The First Affiliated Hospital of Xiamen University, Siming District, Xiamen, Fujian 361003, China

3Department of Urology, Peking University First Hospital and Institute of Urology, Peking University, National Urological Cancer Center, Xicheng District, Beijing 100034, China

4Key Laboratory of Health Technology Assessment of Fujian Province University, School of Public Health, Xiamen University, Xiamen, Fujian 361005, China

*These authors contributed equally to this work and should be considered co-first authors

Correspondence to:

Jinchun Xing, email: [email protected]

Xiurong Wu, email: [email protected]

Keywords: renal sinus fat, progression, survival, non-metastatic, renal cell carcinoma

Received: February 03, 2017     Accepted: June 19, 2017     Published: July 05, 2017

ABSTRACT

In this retrospective study, we evaluated the association between renal sinus fat area (RSFA) and survival in 268 Chinese non-metastatic clear-cell renal cell carcinoma (ccRCC) patients. Patients with high RSFA exhibited better progression-free survival than those with low RSFA in both univariable (HR: 0.240; 95% CI: 0.119–0.482; p < 0.001) and multivariable (HR: 0.432; 95% CI: 0.369–2.749; p = 0.027) analyses. A propensity-score matched (PSM) analysis using Kaplan-Meier curves confirmed our findings (log-rank test; p = 0.028). Based on the multivariable analysis, we constructed a prognostic nomogram with 4 factors, namely, RSFA, Fuhrman grade, AJCC stage and sarcomatoid component. The c-index values for the Leibovich scoring system and the nomogram were 0.762 (95%CI, 0.688–0.835) and 0.823 (95%CI, 0.759–0.888), respectively. These findings demonstrate that high RSFA is associated with better progression-free survival in non-metastatic ccRCC.


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