Clinicopathological and prognostic significance of HMGA2 overexpression in gastric cancer: a meta-analysis

Jingyi Zhu; Hailong Wang; Shuangnian Xu; Yingxue Hao

doi:10.18632/oncotarget.19001

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Meta-Analysis:

Clinicopathological and prognostic significance of HMGA2 overexpression in gastric cancer: a meta-analysis

Jingyi Zhu, Hailong Wang, Shuangnian Xu and Yingxue Hao _

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Oncotarget. 2017; 8:100478-100489. https://doi.org/10.18632/oncotarget.19001

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Abstract

Jingyi Zhu1,*, Hailong Wang1,*, Shuangnian Xu2 and Yingxue Hao1

1 Department of General Surgery, Southwest Hospital of Third Military Medical University, Chongqing, China

2 Department of Hematology, Southwest Hospital of Third Military Medical University, Chongqing, China

* These authors contributed equally to this work; thus, they are co-first authors

Correspondence to:

Yingxue Hao, email:

Keywords: gastric cancer, HMGA2, prognosis, meta-analysis

Received: December 14, 2016 Accepted: June 18, 2017 Published: July 05, 2017

Abstract

Background: High mobility group protein A2 (HMGA2) overexpression has been reported to be closely related to tumor progression [1-4] and indicate significantly worse overall survival in gastric cancer [5-8]. However, a final consensus regarding this issue has not yet been reached. Thus, we conducted a meta-analysis to evaluate the association between HMGA2 expression and prognosis of gastric cancer patients.

Methods: The Cochrane Library, Embase, PubMed, Web of Science and China Biology Medicine databases were searched to identify eligible literature published prior to September 2016. In the included studies, the level of HMGA2 amplification was evaluated by immunohistochemistry. We performed a meta-analysis, and pooled relative risk (RRs), hazard ratio (HRs), and 95% confidence intervals (CIs) were analyzed using Review Manager 5.3.

Results: Six studies [5-7, 9-11] involving 712 gastric cancer patients were included and stratified by HMGA2 amplification magnitude. The results of the analysis indicated that higher HMGA2 levels were associated with several clinicopathological parameters and predicted poor prognosis in terms of overall survival (OS).

Conclusions: The results of the present study indicate that higher HMGA2 levels were significantly associated with TNM stage, lymph node status, vascular invasion, and poor OS in patients with gastric cancer. In conclusion, HMGA2 may serve as a promising prognostic biomarker in gastric cancer.

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Meta-Analysis:

Clinicopathological and prognostic significance of HMGA2 overexpression in gastric cancer: a meta-analysis

Abstract