Clinical Research Papers:

Altered putamen functional connectivity is associated with anxiety disorder in Parkinson’s disease

Xixi Wang, Junyi Li, Yongsheng Yuan, Min Wang, Jian Ding, Jiejin Zhang, Lin Zhu, Yuting Shen, Hui Zhang and Kezhong Zhang _

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Oncotarget. 2017; 8:81377-81386. https://doi.org/10.18632/oncotarget.18996

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Xixi Wang1,*, Junyi Li1,*, Yongsheng Yuan1,*, Min Wang2, Jian Ding1, Jiejin Zhang1, Lin Zhu1, Yuting Shen1, Hui Zhang1 and Kezhong Zhang1

1 Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

2 Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

* These authors have contributed equally to this work

Correspondence to:

Kezhong Zhang, email:

Keywords: Parkinson’s disease, anxiety, resting state functional magnetic resonance imaging, FC, pathogenesis

Received: March 10, 2017 Accepted: June 16, 2017 Published: July 05, 2017


In this study, we used resting state-functional magnetic resonance imaging (rs-fMRI) to explore altered putamen functional connectivity (FC) in Parkinson’s disease patients with anxiety disorder. We divided 65 Parkinson’s disease patients into anxiety (PD-A; n=18) and non-anxiety (PD-NA; n=45) groups based on a Hamilton Anxiety Rating Scale cutoff score of 12. The PD-A patients exhibited altered putamen FC with cortical and subcortical regions. The PD-A patients showed enhanced putamen FC with the caudatum, which correlated with increased emotional processing during anxiety. Decreased putamen FC with the orbitofrontal gyrus and cerebellum also correlated with increased anxiety in Parkinson’s disease. Our findings demonstrate that anxiety disorder in Parkinson’s disease is associated with abnormal putamen FC networks, especially with caudatum, orbitofrontal gyrus and cerebellum.

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PII: 18996