Meta-Analysis:
Association between CD40 rs1883832 and immunerelated diseases susceptibility: A metaanalysis
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Jiaxuan Qin1,2,3, Jinchun Xing1,2,3, Rongfu Liu1,2,3, Bin Chen1,2,3, Yuedong Chen1,2,3 and Xuan Zhuang1,2,3
1Department of Urology Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China
2Center of Diagnosis and Treatment of Urinary System Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China
3The Key Laboratory of Urinary Tract Tumors and Calculi, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China
Correspondence to:
Jinchun Xing, email: [email protected]
Keywords: CD40, rs1883832, immune-related disease, meta-analysis, SNP
Received: May 17, 2017 Accepted: June 17, 2017 Published: June 28, 2017
ABSTRACT
Background/objective: It has been reported that CD40 rs1883832 might be associated with immune-related diseases susceptibility. Owing to mixed and inconclusive results, we conducted a meta-analysis of case–control studies to summarize and clarify this association.
Methods/main results: A systematic search of studies on the association between CD40 rs1883832 and immune-related diseases susceptibility was conducted in databases. Odds ratios and 95% confidence intervals were used to pool the effect size. 40 articles were included in our meta-analysis.
Conclusions: CD40 rs1883832 is associated with decreased risk of Graves’ disease, especially in Asian; CD40 rs1883832 is associated with increased risk of multiple sclerosis; CD40 -1C>T (rs1883832) is not associated with the susceptibility of Hashimoto’s thyroiditis, systemic sclerosis or Asthma; there is insufficient data to fully confirm the association between CD40 rs1883832 and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Behçet's disease (BD), myasthenia gravis (MG), Crohn’s disease (CD), ulcerative colitis (UC), Sarcoidosis, Fuch uveitis syndrome (FUS), Vogt-Koyanagi-Harada syndrome (VKH), Kawasaki disease (KD), giant cell arteritis (GCA) or Immune thrombocytopenia (ITP).