Curcumin protects against hepatic ischemia/reperfusion induced injury through inhibiting TLR4/NF-κB pathway
Metrics: PDF 1792 views | HTML 2979 views | ?
Lu Wang1, Ning Li1, Dongdong Lin1 and Yunjin Zang1
1Department of Surgery and Liver Transplantation Center, Capital Medical University Affiliated Youan Hospital, Beijing, China
Yunjin Zang, email: [email protected]
Keywords: hepatic ischemia reperfusion injury, curcumin, TLR4, NF-κB, inflammatory cytokine
Received: February 25, 2017 Accepted: May 12, 2017 Published: June 27, 2017
The TLR4/NF-κB pathway had important roles in hepatic ischemia/reperfusion (I/R) injury. In this study, we reported a protective effect of curcumin against hepatic I/R injury via TLR4/NF-κB pathway. Curcumin significantly inhibited cell apoptosis, and decreased levels of LDH and production of TNF-a, IL-1b, and IL-6 in the cell supernatant. In addition, curcumin ameliorated elevated TLR4 and NF-κB caused by hypoxia/reoxygenation stimulation in BRL-3A cells. In vivo assays revealed that curcumin reduce levels of ALT and AST, and reversed TLR4/NF-κB signaling pathway caused by hepatic I/R stimulation in liver tissues. These results suggested that curcumin ameliorates hepatic I/R injury, which may be mediated in part via the TLR4/NF-κB signaling pathway.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.