Oncotarget

Research Papers:

Curcumin protects against hepatic ischemia/reperfusion induced injury through inhibiting TLR4/NF-κB pathway

Lu Wang, Ning Li, Dongdong Lin and Yunjin Zang _

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Oncotarget. 2017; 8:65414-65420. https://doi.org/10.18632/oncotarget.18676

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Abstract

Lu Wang1, Ning Li1, Dongdong Lin1 and Yunjin Zang1

1Department of Surgery and Liver Transplantation Center, Capital Medical University Affiliated Youan Hospital, Beijing, China

Correspondence to:

Yunjin Zang, email: [email protected]

Keywords: hepatic ischemia reperfusion injury, curcumin, TLR4, NF-κB, inflammatory cytokine

Received: February 25, 2017     Accepted: May 12, 2017     Published: June 27, 2017

ABSTRACT

The TLR4/NF-κB pathway had important roles in hepatic ischemia/reperfusion (I/R) injury. In this study, we reported a protective effect of curcumin against hepatic I/R injury via TLR4/NF-κB pathway. Curcumin significantly inhibited cell apoptosis, and decreased levels of LDH and production of TNF-a, IL-1b, and IL-6 in the cell supernatant. In addition, curcumin ameliorated elevated TLR4 and NF-κB caused by hypoxia/reoxygenation stimulation in BRL-3A cells. In vivo assays revealed that curcumin reduce levels of ALT and AST, and reversed TLR4/NF-κB signaling pathway caused by hepatic I/R stimulation in liver tissues. These results suggested that curcumin ameliorates hepatic I/R injury, which may be mediated in part via the TLR4/NF-κB signaling pathway.


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