Clinical Research Papers:

Elevated hemoglobin glycation index identify non-diabetic individuals at increased risk of kidney dysfunction

Teresa Vanessa Fiorentino, Maria Adelaide Marini, Elena Succurro, Angela Sciacqua, Francesco Andreozzi, Francesco Perticone and Giorgio Sesti _

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Oncotarget. 2017; 8:79576-79586. https://doi.org/10.18632/oncotarget.18572

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Teresa Vanessa Fiorentino1, Maria Adelaide Marini2, Elena Succurro1, Angela Sciacqua1, Francesco Andreozzi1, Francesco Perticone1 and Giorgio Sesti1

1Department of Medical and Surgical Sciences, Viale Europa, University Magna Græcia of Catanzaro, 88100 Catanzaro, Italy

2Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy

Correspondence to:

Giorgio Sesti, email: [email protected]

Keywords: non-enzymatic protein glycation, kidney dysfunction, hemoglobin glycation index, chronic kidney disease

Received: May 10, 2017     Accepted: June 11, 2017     Published: June 19, 2017


Hemoglobin glycation index (HGI), calculated as the difference between the observed value of HbA1 and the predicted HbA1c based on plasma glucose concentration, is a measure of the individual tendency toward non-enzymatic hemoglobin glycation which has been found to be positively associated with nephropathy in subjects with diabetes. In this cross-sectional study we aimed to evaluate whether higher HGI levels are associated with impaired kidney function also among nondiabetic individuals.

The study group comprised 1505 White nondiabetic individuals stratified in quartiles according to HGI levels. Estimated glomerular filtration rate (eGFR) was calculated by using the MDRD equation.

Individuals in the intermediate and high HGI groups exhibited a worse metabolic phenotype with increased levels of visceral obesity, total cholesterol, triglycerides, inflammatory biomarkers such as hsCRP and white blood cells count and lower values of HDL and insulin sensitivity assessed by Matsuda index in comparison to the lowest quartile of HGI. Subjects in the intermediate and high HGI groups displayed a graded decrease of eGFR levels in comparison with the lowest quartile of HGI. In a logistic regression analysis individuals in the highest quartile of HGI exhibited a significantly 3.6-fold increased risk of having chronic kidney disease (95% CI: 1.13–11.24, P = 0.03) and a significantly 1.6-fold increased risk of having a mildly reduced kidney function (95% CI: 1.19–2.28, P = 0.003) in comparison to individuals in the lowest HGI group.

In conclusion HGI may be a useful tool to identify nondiabetic individuals with an increased risk of having kidney dysfunction.

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