Oncotarget

Clinical Research Papers:

Prognostic factors influencing the survival of patients with carcinoma of the gastric cardia receiving preoperative interventional embolization chemotherapy

Hai-Li Cao, Shu-Qiang Jin, Kai-Bing Wang and Bin Bai _

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Oncotarget. 2017; 8:79567-79575. https://doi.org/10.18632/oncotarget.18571

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Abstract

Hai-Li Cao1, Shu-Qiang Jin1, Kai-Bing Wang1 and Bin Bai1

1Department of Interventional Radiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China

Correspondence to:

Bin Bai, email: baibin811@sina.com

Keywords: prognostic factors, carcinoma of gastric cardia, preoperative interventional embolization chemotherapy, retrospective analysis

Received: August 29, 2016     Accepted: June 02, 2017     Published: June 19, 2017

ABSTRACT

The purpose of this study was to analyze the characteristics of patients with gastric cardia cancer (GCC) to identify the main factors the influence the survival rate after interventional embolization chemotherapy (IEC). One hundred and fifty-six patients with advanced GCC were treated with IEC via the left gastric artery. Survival time was defined as from the date of diagnosis until death or the end of this study in June 2015. The median survival time was 15 months (range 3 to 29 months). The Cox proportional hazard model found that patients’ age (p < 0.001), sex (p = 0.039), weight loss more than 10% in the prior 3 months (p = 0.014), body mass index (BMI) (p = 0.047), and hematocrit value less than 37% (p < 0.001) were correlated with mortality after removal of cases of poorly differentiated carcinoma and undifferentiated carcinoma from the analysis. Kaplan-Meier curves of survival according to patients’ age showed significant differences by the log-rank test (p = 0.0015). The median survival time was 17 months among patients of aged < 50 years. In conclusion, BMI, weight loss > 10% in the prior 3 months, albumin, and hematocrit were prognostic indicators for patients with advanced GCC, and patients younger than 50 years have a higher survival rate after IEC.


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