Oncotarget

Research Papers:

Proton pump inhibitors increase the chemosensitivity of patients with advanced colorectal cancer

Xiaoyu Wang, Chun Liu, Jiaqi Wang _, Yue Fan, Zhenghua Wang and Yuanyuan Wang

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Oncotarget. 2017; 8:58801-58808. https://doi.org/10.18632/oncotarget.18522

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Abstract

Xiaoyu Wang1, Chun Liu2, Jiaqi Wang3, Yue Fan4, Zhenghua Wang1 and Yuanyuan Wang1

1Third Ward of Oncology Department, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, 121001, China

2Department of Biochemistry, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110001, China

3Traditional Chinese Medicine Department, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, 121001, China

4Jinzhou Medical University, Jinzhou, Liaoning, 121001, China

Correspondence to:

Jiaqi Wang, email: zyjiaqi@126.com

Keywords: PPI, chemosensitization, 5-FU, FOLFOX, capeOx

Received: February 10, 2017     Accepted: June 05, 2017     Published: June 16, 2017

ABSTRACT

Changes in pH can alter the uptake of chemotherapy drugs. Proton pump inhibitors (PPIs) may therefore increase the chemosensitivity of cancer cells and cytotoxicity of chemotherapeutic drugs by increasing their uptake. We investigated the chemosensitizing potential of PPIs in colorectal cancer (CRC). Our in vitro data show that the PPI pantoprazole increases the chemosensitivity of CRC HT29 and RKO cells to fluorouracil (5-FU). Our in vivo data demonstrate that pantoprazole also increases the ability of 5-FU to inhibit CRC tumor growth in mice. Importantly, a retrospective clinical study of CRC patients receiving the FOLFOX or CapeOx regimen indicates that PPIs increase the chemosensitivity of CRC patients. Patients who received the FOLFOX regimen with a PPI had better overall survival (OS) and progression-free survival (PFS) than patients who did not receive a PPI during FOLFOX chemotherapy. The incidence of nausea and vomiting was also lower in patients receiving a PPI with FOLFOX or CapeOx than in those who did not receive PPI. These results indicate that PPIs may be successfully incorporated into the FOLFOX regimen to increase the chemotherapeutic effect for CRC patients.


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