Oncotarget

Reviews:

Intersecting transcriptomic profiling technologies and long non-coding RNA function in lung adenocarcinoma: discovery, mechanisms, and therapeutic applications

Jonathan Castillo, Theresa R. Stueve and Crystal N. Marconett _

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Oncotarget. 2017; 8:81538-81557. https://doi.org/10.18632/oncotarget.18432

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Abstract

Jonathan Castillo1,2,3, Theresa R. Stueve2 and Crystal N. Marconett1,2,3

1 Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

2 Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

3 Department of Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

Correspondence to:

Crystal N. Marconett, email:

Keywords: LncRNA biology, transcriptomic analysis, lung adenocarcinoma, cancer, RNA biology

Received: October 19, 2016 Accepted: March 13, 2017 Published: June 09, 2017

Abstract

Previously thought of as junk transcripts and pseudogene remnants, long non-coding RNAs (lncRNAs) have come into their own over the last decade as an essential component of cellular activity, regulating a plethora of functions within multicellular organisms. lncRNAs are now known to participate in development, cellular homeostasis, immunological processes, and the development of disease. With the advent of next generation sequencing technology, hundreds of thousands of lncRNAs have been identified. However, movement beyond mere discovery to the understanding of molecular processes has been stymied by the complicated genomic structure, tissue-restricted expression, and diverse regulatory roles lncRNAs play. In this review, we will focus on lncRNAs involved in lung cancer, the most common cause of cancer-related death in the United States and worldwide. We will summarize their various methods of discovery, provide consensus rankings of deregulated lncRNAs in lung cancer, and describe in detail the limited functional analysis that has been undertaken so far.


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