Ovarian preservation improves overall survival in young patients with early-stage endometrial cancer
Metrics: PDF 1083 views | HTML 1903 views | ?
Peng Jia1 and Yan Zhang1
1Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, People's Republic of China
Yan Zhang, email: firstname.lastname@example.org
Keywords: endometrial cancer, early-stage, ovarian preservation, young women, meta-analysis
Received: March 31, 2017 Accepted: May 28, 2017 Published: June 07, 2017
We searched Medline, Embase, Cochrane library, the Chinese Biomedicine Literature Database, the Chinese Scientific Journal Full-text Database, the Chinese Journal Full-text Database, and the Wanfang Database to collect observational studies on the effects of ovary-saving surgery in comparison to bilateral salpingo-oophorectomy (BSO) in young patients with early-stage endometrial cancer (EC). The literature search included studies up to March 2017, and 10 retrospective cohort studies met our selection criteria. Random and fixed effect models revealed that ovarian preservation (OP) was associated with better overall survival (OS) (hazard ratio [HR] 0.75, 95% confidence interval [CI] 0.57–0.99, P = 0.044), and was not associated with reduced recurrence-free survival (RFS) in pre-menopausal patients with early-stage endometrial cancer (HR 1.22, 95% CI 0.32–4.72, P = 0.648; risk ratio [RR] 1.11, 95% CI 0.59–2.10, P = 0.745). Preservation of the ovaries appears to be a safe option with significant benefit for this low risk population after a thorough preoperative evaluation and extensive intraoperative exploration.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.