The miR-200 family in ovarian cancer

Maria Koutsaki, Massimo Libra, Demetrios A. Spandidos and Apostolos Zaravinos _

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Oncotarget. 2017; 8:66629-66640. https://doi.org/10.18632/oncotarget.18343

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Maria Koutsaki1, Massimo Libra2, Demetrios A. Spandidos3 and Apostolos Zaravinos4

13rd Department of Pediatrics of the National and Kapodistrian University of Athens, Attikon University Hospital, 12462 Athens, Greece

2Department of Biomedical and Biotechnological Sciences, Laboratory of Translational Oncology and Functional Genomics, Section of General and Clinical Pathology and Oncology, University of Catania, 95124 Catania, Italy

3Laboratory of Virology, Medical School, University of Crete, 71110 Heraklion, Crete, Greece

4Department of Life Sciences, School of Sciences, European University Cyprus, 1516 Nicosia, Cyprus

Correspondence to:

Apostolos Zaravinos, email: [email protected]

Keywords: miR-200 family, ovarian cancer, prognosis, disease stage, tumor histology

Received: December 06, 2016     Accepted: May 22, 2017     Published: June 02, 2017


Ovarian cancer (OC) is the most lethal gynecological malignancy. Its insidious nature, manifesting with little to no symptoms until the disease progresses to metastasis, along with a wide diversity of histological subtypes and corresponding clinical behavior, poses significant therapeutic challenges. The genetic profiling of this aggressive tumor and its subtypes has led to the identification of various molecular markers of prognosis. Among these, the miR-200 family of miRNAs appears to play an important role. The deregulated expression of the miR-200 family members has been detected in a variety of OC studies. The present review examines the potential usefulness of the miR-200 family members as prognostic indicators in ovarian cancer and their impact across different OC publications, with a particular focus on prognostic features, such as disease stage, tumor histology, survival and response to chemotherapy. We present the potential usefulness of the miR-200 family genes as prognostic indicators in OC and highlight the tendency that miR-200 overexpression corresponds with an advanced cancer stage.

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