Oncotarget

Clinical Research Papers:

Association of miR-146a, miR-149, miR-196a2, miR-499 gene polymorphisms with ischemic stroke in a Chinese people

Hong-Cheng Luo, Qi-sheng Luo, Chun-Fang Wang, Ming Lei, Bei-Lin Li and Ye-Sheng Wei _

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Oncotarget. 2017; 8:81295-81304. https://doi.org/10.18632/oncotarget.18333

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Abstract

Hong-Cheng Luo1,*, Qi-sheng Luo2,*, Chun-Fang Wang1, Ming Lei1, Bei-Lin Li1 and Ye-Sheng Wei1

1Department of Laboratory Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, Guangxi, China

2Department of Neurosurgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, Guangxi, China

*These authors contributed equally to this work

Correspondence to:

Ye-Sheng Wei, email: weizhuren999@163.com

Keywords: allele, genotype, ischemic stroke, microRNA, single nucleotide polymorphism

Received: October 22, 2016     Accepted: March 21, 2017     Published: June 01, 2017

ABSTRACT

This study aimed to investigate genetic polymorphisms of miR-146a, miR-149, miR-196a2, and miR-499 and genetic susceptibility of ischemic stroke in the population of Guangxi in China. A case–control study was used to investigate miRNAs genetic polymorphisms in 298 patients with ischemic stroke and 303 healthy controls. Single-base extension polymerase chain reaction genotyping principle was used to detect genetic polymorphisms of miRNAs,and the relationship of genotype in each group and blood lipid was compared and analyzed. The genetic polymorphism of miR-499A>G (rs3746444) was associated with ischemic stroke (P < 0.05), and the risk of ischemic stroke was high in patients with G allele (OR = 1.455; 95% CI = 0.531–2.381; P = 0.039) and AG (OR = 1.339; 95% CI = 1.126–1.967; P = 0.037) genotype. The levels of low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, homocysteine, and lipoprotein in the ischemic stroke group were higher than those in the control group (P < 0.05). The genetic polymorphism of miR-499A>G (rs3746444) was related to ischemic stroke, and G allele and AG genotype may increase the risk of ischemic stroke in the population of Guangxi in China.


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