Higher platelet distribution width predicts poor prognosis in laryngeal cancer
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Huan Zhang1,*, Li Liu2,*, Shuang Fu1,*, Yan-Song Liu3, Changsong Wang3, Tiemin Liu1,4, Zhi-Ping Liu5, Rui-Tao Wang1,6 and Kai-Jiang Yu3,6
1Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, 150081, China
2Department of Histology and Embryology, Harbin Medical University, Harbin, Heilongjiang, 150081, China
3Department of Intensive Care Unit, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, 150081, China
4Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA
5Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA
6Heilongjiang Academy of Medical Science, Harbin, Heilongjiang, 150081, China
*These authors have contributed equally to this work
Rui-Tao Wang, email: email@example.com
Kai-Jiang Yu, email: firstname.lastname@example.org
Keywords: laryngeal cancer, platelet distribution width, prognosis, survival
Received: March 29, 2017 Accepted: May 01, 2017 Published: May 30, 2017
Background: Activated platelets promote cancer progression and metastasis. However, the prognostic value of platelet indices in laryngeal cancer remains poorly understood. The purpose of this study was to investigate the predictive significance of platelet indices in laryngeal cancer.
Results: Of the 241 patients, high platelet distribution width (PDW) levels were observed in 116 (48.1 %) patients. In the Kaplan-Meier analysis, increased PDW was significantly associated with a poorer overall survival (p < 0.001). In the multivariate Cox model, PDW was an independent prognostic index for overall survival (HR=4.381, 95% CI=2.313-8.298, P < 0.001).
Method: The retrospective study included 241 consecutive patients with laryngeal cancer between January 2009 and December 2009. The relationships between PDW and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of PDW.
Conclusions: Elevated PDW might be a novel prognostic marker in laryngeal cancer.
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