Clinical Research Papers:
Prognostic value of systemic inflammation score in patients with hepatocellular carcinoma after hepatectomy
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Shiming Shi1,*, Qing Chen2,3,*, Luxi Ye1, Dan Yin2,4, Xuedong Li2, Zhi Dai2 and Jian He1
1 Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, P.R. China
2 Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, P.R. China
3 Department of General Surgery, Zhongshan Hospital South, Fudan University, Shanghai Public Health Clinical Center, Fudan University, Shanghai, P.R. China
4 Institute of Biomedical Sciences, Fudan University, Shanghai, P.R. China
* These authors have contributed equally to this work
Jian He, email:
Zhi Dai, email:
Keywords: hepatocellular carcinoma; blood lymphocyte-to-monocyte ratio; gamma-glutamyltransferase; systemic inflammation score; hepatectomy
Received: January 12, 2017 Accepted: April 24, 2017 Published: May 24, 2017
Inflammation plays an important role in cancer progression. In this study, we aimed to investigate the prognostic value of the systemic inflammatory biomarkers in hepatocellular carcinoma (HCC) patients undergoing curative resection. Data from 271 HCC patients who underwent curative resection in Zhongshan Hospital between 2008 and 2011 were included. Kaplan-Meier survival analysis showed that gamma-glutamyltransferase (GGT) and lymphocyte-to-monocyte ratio (LMR) were significantly associated with overall survival(OS) and time to recurrence(TTR). We created a systemic inflammation score (SIS) basing on preoperative serum GGT and LMR. Low SIS was also significantly associated with increased OS and TTR. Univariate and multivariate analyses revealed the LMR, GGT and SIS were independent predictors for OS and TTR. The predictive ability of the SIS, as assessed by area under the receiver operating characteristic curve, was 0.682 (95% CI, 0.618-0.746) for OS, which was higher than GGT and LMR. In conclusion, low preoperative LMR and high preoperative GGT were associated with a poor prognosis in HCC patients after hepatectomy. Our results confirmed that the SIS qualifies as a novel prognostic predictor of HCC patients after hepatectomy.
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