Clinical Research Papers:

Chemotherapy-induced changes of cerebral activity in resting-state functional magnetic resonance imaging and cerebral white matter in diffusion tensor imaging

Caiqin Mo, Hailong Lin, Fangmeng Fu, Lin Lin, Jie Zhang, Meng Huang, Chuan Wang _, Yunjing Xue, Qing Duan, Weiwen Lin and Xiangjin Chen

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Oncotarget. 2017; 8:81273-81284. https://doi.org/10.18632/oncotarget.18111

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Caiqin Mo2,*, Hailong Lin3,*, Fangmeng Fu1,*, Lin Lin3,*, Jie Zhang1,*, Meng Huang4, Chuan Wang1, Yunjing Xue3, Qing Duan3, Weiwen Lin3 and Xiangjin Chen2

1 Department of Breast Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou, China

2 Department of Thyroid and Breast Surgery, First Affiliated Hospital of Fujian Medical University, Fuzhou, China

3 Radiology Department, Affiliated Union Hospital of Fujian Medical University, Fuzhou, China

4 Fujian Center for Disease Control and Prevention, Fuzhou, China

* These authors have contributed equally to this work

Correspondence to:

Chuan Wang, email:

Xiangjin Chen, email:

Keywords: breast cancer, chemotherapy, cognitive disorder, resting-state functional magnetic resonance imaging, diffusion tensor imaging

Received: October 12, 2016 Accepted: May 08, 2017 Published: May 23, 2017


While chemotherapy related cognitive disorder has been described in many studies, but we still lack relatively reliable and objective diagnostic tools, and there are few similar studies in Asian patients. We recruited Asian breast cancer patients to perform a cohort study to uncover chemotherapy related cognitive disorder by using resting-state functioning magnetic resonance imaging (RS-fMRI) and magnetic resonance diffusion tensor imaging (DTI) combined with neuropsychologic assessments. This is the first prospective study which combines RS-fMRI and DTI to detect chemotherapy related cognitive disorder. The neuropsychologic tests and MRI were performed before and after the chemotherapy. The healthy controls were tested at matched times. The chemotherapy-treated group performed worse on memory and we found significant changes in the cerebellum, right orbitofrontal area, right middle and superior temporal gyrus, right subcentral area, left dorsolateral prefrontal cortex, and precentral gyrus in RS-fMRI after chemotherapy. We found changes in the fornix and superior fronto-occipital fasciculus with DTI. There was a correlation between some cognitive function and MRI measurements in the correlation analysis, but it was not significant after false discovery rate (FDR) multiple testing corrections. The results indicate that RS-fMRI and DTI may be a prospective application for assessing chemotherapy related cognitive disorder.

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