This article has been corrected. Correction in: Oncotarget. 2018; 9:6657.

The optimal time of initiation of renal replacement therapy in acute kidney injury: A meta-analysis

Kaiping Luo, Shufang Fu, Weidong Fang and Gaosi Xu _

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Oncotarget. 2017; 8:68795-68808. https://doi.org/10.18632/oncotarget.17946

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Kaiping Luo1,*, Shufang Fu1,*, Weidong Fang2 and Gaosi Xu1

1Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, China

2Department of Nephrology, People's Hospital of Ganzhou, Ganzhou, China

*These authors have contributed equally to this work

Correspondence to:

Gaosi Xu, email: [email protected]

Keywords: acute kidney injury, renal replacement therapy, mortality, meta-analysis

Received: January 09, 2017     Accepted: March 30, 2017     Published: May 16, 2017


Background: The impact on the timing of renal replacement therapy (RRT) initiation on clinical outcomes for patients with acute kidney injury (AKI) remains controversial.

Materials and methods: We searched the Cochrane Library, EMBASE, Global Health, MEDLINE, PubMed, the International Clinical Trials Registry Platform, and Web of Science.

Results: We included 49 studies involving 9698 patients. Pooled analysis of 5408 critically ill patients with AKI showed that early RRT was significantly associated with reduced mortality compared to late RRT [odds ratio (OR), 0.40; 95% confidential intervals (CI), 0.32 - 0.48; I2, 50.2%]. For 4290 non-critically ill patients with AKI, there was no statistically significant difference in the risk of mortality between early and late RRT (OR, 1.07; 95% CI, 0.79 - 1.45; I2, 73.0%). Early RRT was markedly associated with shortened intensive care units (ICU) length of stay (LOS) and hospital LOS compared to late RRT in both critically ill and non-critically ill patients with AKI.

Conclusions: Early RRT probably reduce the mortality, ICU and hospital LOS in critically ill patients with AKI. Inversely, early RRT in non-critically ill patients with AKI did not decrease the mortality, but shortened the ICU and hospital LOS.

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