Increased expression of long non-coding RNA CCEPR is associated with poor prognosis and promotes tumorigenesis in urothelial bladder carcinoma
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Yonghao Zhan1,2,*, Yifan Li1,*, Bao Guan1,*, Xiaoying Chen1,2, Zhicong Chen1,2, Anbang He1,2, Shiming He1, Yanqing Gong1, Ding Peng1, Yuchen Liu1,2, Zhiming Cai1,2, Xuesong Li1 and Liqun Zhou1
1Department of Urology, Peking University First Hospital, The Institute of Urology, Peking University, National Urological Cancer Centre, Beijing, 100034, China
2Department of Urology, State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology, Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, China
*These authors have contributed equally to this work
Liqun Zhou, email: [email protected]
Xuesong Li, email: [email protected]
Keywords: bladder cancer, biomarker, lncRNA CCEPR, PCNA, tumorigenesis
Received: October 12, 2016 Accepted: April 22, 2017 Published: May 15, 2017
Recent emerging evidences have showed that long non-coding RNAs play important regulatory roles in diverse biological processes of tumor development and progression. CCEPR (cervical carcinoma expressed PCNA regulatory lncRNA) is a novel identified lncRNA that acts as a potential biomarker and involves in development and progression of cervical carcinoma. Nevertheless, we know nothing about the clinical significance and molecular mechanism of CCEPR in bladder cancer. In this study, we found that CCEPR was significantly up-regulated in bladder cancer. Furthermore, up-regulated CCEPR expression was positively correlated with advanced TNM stage and higher histological grade. Moreover, further experiments demonstrated that CCEPR promotes cell proliferation and suppresses cell apoptosis in bladder cancer. Mechanistically, we found CCEPR upregulates the expression of PCNA in mRNA and protein level to promote cancer growth. In conclusions, these findings demonstrated that CCEPR plays an important regulatory role in bladder cancer and may serve as a potential diagnostic biomarker and therapeutic target.
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