Research Papers:

Intravoxel incoherent motion diffusion-weighted MR imaging parameters predict pathological classification in thymic epithelial tumors

Gang-Feng Li, Shi-Jun Duan, Lin-Feng Yan, Wen Wang, Yong Jing, Wei-Qiang Yan, Qian Sun, Shu-Mei Wang, Hai-Yan Nan, Tian-Yong Xu, Dan-Dan Zheng, Yu-Chuan Hu and Guang-Bin Cui _

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Oncotarget. 2017; 8:44579-44592. https://doi.org/10.18632/oncotarget.17857

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Gang-Feng Li1,*, Shi-Jun Duan1,*, Lin-Feng Yan1,*, Wen Wang1, Yong Jing1, Wei-Qiang Yan1, Qian Sun1, Shu-Mei Wang2, Hai-Yan Nan1, Tian-Yong Xu3, Dan-Dan Zheng3, Yu-Chuan Hu1 and Guang-Bin Cui1

1Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi’an, China

2Department of Pathology, Tangdu Hospital, Fourth Military Medical University, Xi’an, China

3MR Research China, GE Healthcare China, Beijing, China

*These authors have contributed equally to this work

Correspondence to:

Guang-Bin Cui, email: [email protected]

Yu-Chuan Hu, email: [email protected]

Keywords: thymic epithelial tumor, intravoxel incoherent motion, DWI, masaoka stage, pathological type

Received: February 28, 2017    Accepted: April 12, 2017    Published: May 15, 2017


We evaluated the performance of intravoxel incoherent motion (IVIM) parameters for preoperatively predicting the subtype and Masaoka stage of thymic epithelial tumors (TETs). Seventy-seven patients with pathologically confirmed TETs underwent a diffusion weighted imaging (DWI) sequence with 9 b values. Differences in the slow diffusion coefficient (D), fast perfusion coefficient (D*), and perfusion fraction (f) IVIM parameters, as well as the multi b-value fitted apparent diffusion coefficient (ADCmb), were compared among patients with low-risk (LRT) and high-risk thymomas (HRT) and thymic carcinomas (TC), and between early stage (stages I and II) and advanced stage (stages III and IV) TET patients. ADCmb, D, and D* values were higher in the LRT group than in the HRT or TC group, but did not differ between the HRT and TC groups. The mean ADCmb, D, and D* values were higher in the early stage TETs group than the advanced stage TETs group. The f values did not differ among the groups. These results suggest that IVIM DWI could be used to preoperatively predict subtype and Masaoka stage in TET patients.

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