Clinical Research Papers:

Correlation of HAMP gene polymorphisms and expression with the susceptibility and length of hospital stays in Taiwanese children with Kawasaki disease

Ying-Hsien Huang, Kuender D. Yang, Yu-Wen Hsu, Hsing-Fang Lu, Henry Sung-Ching Wong, Hong-Ren Yu, Hsing-Chun Kuo, Fu-Chen Huang, Mao-Hung Lo, Kai-Sheng Hsieh, Su-Fen Chen, Wei-Chiao Chang and Ho-Chang Kuo _

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Oncotarget. 2017; 8:51859-51868. https://doi.org/10.18632/oncotarget.17700

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Ying-Hsien Huang1,*, Kuender D. Yang2,*, Yu-Wen Hsu3,4,*, Hsing-Fang Lu4,5, Henry Sung-Ching Wong4,6, Hong-Ren Yu1, Hsing-Chun Kuo7,8,9, Fu-Chen Huang1, Mao-Hung Lo1, Kai-Sheng Hsieh1, Su-Fen Chen11, Wei-Chiao Chang4,6,10 and Ho-Chang Kuo1,6

1Department of Pediatrics and Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan

2Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Department of Pediatrics, Mackay Memorial Hospital, Taipei, and Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan

3The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei, Taiwan

4Department of Clinical Pharmacy, Taipei Medical University, Taipei, Taiwan

5Department of Pharmacy, Taipei Medical University-Shuang Ho Hospital, Taipei, Taiwan

6Master’s Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei, Taiwan

7Department of Nursing, Chang Gung University of Science and Technology, Chiayi, Taiwan

8Research Center for Industry of Human Ecology and Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan

9Chronic Diseases and Health Promotion Research Center, CGUST, Chiayi, Taiwan

10Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Kaohsiung, Taiwan

11Department of Pharmacy, St Vincent Medical Center, Los Angeles, California, USA

*These authors contributed equally to this work

Correspondence to:

Ho-Chang Kuo, email: [email protected]

Wei-Chiao Chang, email: [email protected]

Keywords: hepcidin, genetic polymorphism, kawasaki disease

Received: August 26, 2016     Accepted: March 27, 2017     Published: May 08, 2017


Kawasaki disease (KD) is a form of systemic vasculitis. Regarding its pathogenesis, HAMP gene encoding hepcidin, which is significant for iron metabolism, has a vital function. In this study, we recruited a total of 381 KD patients for genotyping. Data from 997 subjects (500 subjects from cohort 1; 497 subjects from cohort 2) were used for analysis. Using TaqMan allelic discrimination, we determined five tag SNPs (rs916145, rs10421768, rs3817623, rs7251432, and rs2293689). Treatment outcome data related to such clinical phenotypes as coronary artery lesions (CAL), coronary artery aneurysms (CAA), and intravenous immunoglobulin (IVIG) effects were also collected. Furthermore, we measured plasma hepcidin levels with an enzyme-linked immunosorbent assay. We found that HAMP gene polymorphism (rs7251432, and rs2293689) was significantly correlated with KD risk and that plasma hepcidin levels both before and after IVIG treatment had a significantly positive correlation with length of hospital stays (R = 0.217, p = 0.046 and R = 0.381, p < 0.0001, respectively). In contrast, plasma hepcidin levels has a negative correlation with KD patients’ albumin levels (R = −0.27, p < 0.001) prior to IVIG treatment. This study’s findings indicate that HAMP might have a role in the disease susceptibility, as well as its expressions correlated length of hospital stays, and albumin levels in Taiwanese children with KD.

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