Clinical Research Papers:

Association between body mass index and presence of carotid plaque among low-income adults aged 45 years and older: a population-based cross-sectional study in rural China

Yongzhong Lou _, Bin Li, Lan Su, Zhenhong Mu, Minghao Sun, Hongfei Gu, Jingxian Ni, Yanan Wu, Jun Tu, Jinghua Wang and Xianjia Ning

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Oncotarget. 2017; 8:81261-81272. https://doi.org/10.18632/oncotarget.17608

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Yongzhong Lou1, Bin Li1, Lan Su1, Zhenhong Mu1, Minghao Sun1, Hongfei Gu1, Jingxian Ni2,3,4, Yanan Wu2,3,4, Jun Tu2,3,4, Jinghua Wang3,4,5 and Xianjia Ning3,4,5

1 Department of Neurology, Tianjin Haibin People’s Hospital, Tianjin, China

2 Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China

3 Department of Epidemiology, Tianjin Neurological Institute, Tianjin, China

4 Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, China

5 Center of Clinical Epidemiology, Tianjin Medical University General Hospital, Tianjin, China

Correspondence to:

Bin Li, email:

Xianjia Ning, email:

Keywords: carotid plaque, body mass index, ultrasonography, low-income population, epidemiology

Received: February 08, 2017 Accepted: April 17, 2017 Published: May 04, 2017


Carotid plaque is a good surrogate endpoint for assessing arterial atherosclerosis, and atherosclerosis is a reliable predictor of cardiovascular diseases. However, the effect of body mass index on carotid plaque is unknown. Therefore, we aimed to explore the association between body mass index and carotid plaque in a low-income Chinese population. Residents aged ≥45 years and free of stroke and cardiovascular diseases were enrolled and divided into four groups based on body mass index. B-mode ultrasonography was performed to measure carotid plaque. The mean age of participants was 59.92 years overall. Significant correlations were observed between the presence of carotid plaque and male sex, older age, systolic blood pressure, fasting plasma glucose, and low-density lipoprotein cholesterol among the different BMI subgroups. Male sex increased the risk of carotid plaque in the overweight and obese groups. Older age and high level of low-density lipoprotein cholesterol were the independent risk factor for carotid plaque in four groups. Increased systolic blood pressure was an independent risk factor in the normal-weight, overweight, and obese groups; however, fasting plasma glucose was only significant in the normal-weight group. Thus, controlling the levels of low-density lipoprotein cholesterol, systolic blood pressure, and fasting plasma glucose is required to reduce carotid plaque risk.

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PII: 17608