Oncotarget

Research Papers:

Role of intravoxel incoherent motion MR imaging in preoperative assessing HER2 status of gastric cancers

Changfeng Ji, Qinglei Zhang, Wenxian Guan, Tingting Guo, Ling Chen, Song Liu _, Jian He and Zhengyang Zhou

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Oncotarget. 2017; 8:49293-49302. https://doi.org/10.18632/oncotarget.17570

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Abstract

Changfeng Ji1,*, Qinglei Zhang1,*, Wenxian Guan2, Tingting Guo3, Ling Chen4, Song Liu1, Jian He1 and Zhengyang Zhou1

1Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China, 210008

2Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China, 210008

3Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China, 210008

4Department of Pathology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China, 210008

*These authors contributed equally to this work

Correspondence to:

Song Liu, email: liusongnj@126.com

Jian He, email: hjxueren@126.com

Zhengyang Zhou, email: zyzhou@nju.edu.cn

Keywords: intravoxel incoherent motion, magnetic resonance imaging, stomach neoplasm, human epidermal growth factor receptor 2, immunohistochemistry

Received: December 14, 2016     Accepted: April 17, 2017     Published: May 02, 2017

ABSTRACT

Purpose: To explore the role of intravoxel incoherent motion (IVIM) magnetic resonance (MR) imaging in evaluating human epidermal growth factor receptor 2 (HER2) status of gastric cancers preoperatively.

Results: The apparent diffusion coefficient (ADC) and pure diffusion coefficient (D) values correlated positively with HER2 scores of gastric cancers significantly (r = 0.276, P = 0.048; r = 0.481, P < 0.001, respectively). The ADC and D values of HER2 positive gastric cancers were significantly higher than those of HER2 negative tumors (P = 0.033, 0.007, respectively). With a cut-off value of 1.321 and 1.123 × 10−3 mm2/sec, the ADC and D values could distinguish HER2 positive gastric cancers from HER2 negative ones with an area under the curve of 0.733 and 0.762, respectively (P = 0.023, 0.011, respectively).

Materials and methods: Fifty-three patients with gastric cancers underwent IVIM MR imaging preoperatively. The values of ADC, D, pseudo diffusion coefficient (D*) and perfusion related fraction (f) of the lesions were obtained. Partial correlation test including tumor volume was performed to analyze correlations between IVIM values and HER2 scores excluding the impact of tumor size. IVIM parameters of gastric cancers with different HER2 status were compared using independent samples t test. Diagnostic performance of IVIM parameters in distinguishing HER2 positive gastric cancers from negative ones was tested with receiver operating characteristic analysis.

Conclusions: We confirmed the feasibility of IVIM MR imaging in preoperative assessment of HER2 status of gastric cancers, which might make up the shortfall of biopsy and facilitate personalized treatment for patients with gastric cancers.


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