Prognostic significance of soluble mesothelin in malignant pleural mesothelioma: a meta-analysis
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Long Tian1,*, Rujun Zeng2,*, Xin Wang1,*, Cheng Shen1, Yutian Lai1, Mingming Wang1 and Guowei Che1
1Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China
2Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China
*These authors have contributed equally to this work
Guowei Che, email: [email protected]
Keywords: soluble mesothelin, malignant pleural mesothelioma, prognosis, meta-analysis
Abbreviations: MPM: malignant pleural mesothelioma; CI: confidence interval; HR: hazard ratio
Received: November 30, 2016 Accepted: April 10, 2017 Published: April 26, 2017
Background: Soluble mesothelin is beneficial to detect the progression and the treatment response of malignant pleural mesothelioma. However, the prognostic value of soluble mesothelin in malignant pleural mesothelioma remains unclear.
Methods: Hazard ratio with 95% CI was used to evaluate the prognostic value of soluble mesothelin and the effect of clinicopathological characteristics on the survival of malignant pleural mesothelioma.
Results: Eight eligible studies involving 579 patients were selected for this meta-analysis. The results showed that soluble mesothelin level was significantly correlated with the survival of malignant pleural mesothelioma (pooled HR: 1.958, 95%CI: 1.531-2.504, p = 0.000; heterogeneity test: I2 = 1.1%, p = 0.421). In addition, the survival of malignant pleural mesothelioma was significantly correlated with some clinicopathological characteristics such as tumor histology (HR = 3.214, 95% CI = 2.071-4.988, p = 0.000; heterogeneity test: I2 = 0.0%, p = 0.623) and tumor stage (HR = 2.007; 95% CI = 1.477-2.727; p = 0.000; heterogeneity test: I2 = 0.0%, p = 0.966).
Conclusions: The survival of malignant pleural mesothelioma is significantly correlated with tumor histology and tumor stage. Furthermore, high soluble mesothelin level may lead to a poor prognosis for malignant pleural mesothelioma patients.
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