Clinical Research Papers:
CT-guided microwave ablation through the lungs for treating liver tumors near the diaphragm
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Han Qi1,*, Hao Zhang2,*, Chao Wan1,*, Lin Xie1, Ze Song1 and Weijun Fan1
1Department of Imaging and Interventional Radiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China
2Department of Interventional Medical Center, The Affiliated Hospital of Qingdao University, Qingdao, China
*These authors have contributed equally to this work
Weijun Fan, email: [email protected]
Keywords: CT-guidance, microwave ablation, liver tumor, diaphragm, treatment
Abbreviations: MWA: microwave ablation; CR: complete response; ICR: incomplete response; LR: local recurrence; KPS: Karnofsky Scal
Received: October 24, 2016 Accepted: March 20, 2017 Published: April 26, 2017
Purpose: To explore the short-term efficacy and safety of CT-guided microwave ablation (MWA) for treating liver tumors near the diaphragm.
Results: The complete response (CR) rate for CT-guided MWA through the lung was 94.7% (124/131). The incomplete response (ICR) rate was 5.3% (7/131), of which 6 patients with ICRs achieved CRs after MWA. The CR rate for Group I was higher than Group II (99.0% vs. 80.0%, P=0.001). The mean follow-up time was 11.2 ±7.50 months. The total local recurrence (LR) rate was 15.3% (20/131). The complication rate was 26.5%, and no severe complications were recorded. All complications were controllable and treatable. The incidence of diaphragmatic thickening during the MWA was 18.8% (P>0.05); the incidence of exudative changes inside the lungs was 6.8% (P>0.05).
Conclusions: CT-guided MWA can detect changes in liver tissue, in the diaphragm and nearby lung tissues during the ablation process. It’s safe and effective to treat tumors close to the diaphragm by CT-guided MWA through the lung.
Methods: CT-guided MWA was used on 131 tumors that were close to the diaphragm (distance between tumor and diaphragm ≤ 5 mm) in 117 patients with liver cancer. The tumors were divided into a < 3.0 cm group (Group I, n= 101) and a ≥ 3.0 cm group (Group II, n= 30) based on tumor diameters. The complications within 2 weeks following treatment were counted, and the safety and short-term efficacy of MWA were analyzed.
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