Research Papers:

Genetic variation and forensic efficiency of autosomal insertion/deletion polymorphisms in Chinese Bai ethnic group: phylogenetic analysis to other populations

Chun-Hua Yang, Cai-Yong Yin, Chun-Mei Shen, Yu-Xin Guo, Qian Dong, Jiang-Wei Yan, Hong-Dan Wang, Yu-Dang Zhang, Hao-Tian Meng, Rui Jin, Feng Chen and Bo-Feng Zhu _

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Oncotarget. 2017; 8:39582-39591. https://doi.org/10.18632/oncotarget.17137

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Chun-Hua Yang1,2,3,*, Cai-Yong Yin4,*, Chun-Mei Shen3,5, Yu-Xin Guo1,2, Qian Dong1,2, Jiang-Wei Yan6, Hong-Dan Wang7, Yu-Dang Zhang8, Hao-Tian Meng1,2, Rui Jin9, Feng Chen4,** and Bo-Feng Zhu1,2,3,**

1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, P. R. China

2Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, P. R. China

3Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong, P. R. China

4Department of Forensic Medicine, Nanjing Medical University, Nanjing, Jiangsu, P. R. China

5Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, P. R. China

6Key Laboratory of Genome Sciences, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, P. R. China

7Medical Genetic Institute of Henan Province, People's Hospital of Henan Province, Zhengzhou, Henan, P. R. China

8Institue of Forensic Sciences of Anhui Public Security Department, Hefei, Anhui, P. R. China

9Department of Radiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China

*Co-first authors

**These authors contributed equally to this work

Correspondence to:

Bo-Feng Zhu, email: [email protected]

Keywords: Indel, Bai group, phylogenetic analysis, population genetics

Received: January 09, 2017     Accepted: February 17, 2017     Published: April 17, 2017


Thirty insertion/deletion loci were utilized to study the genetic diversities of 125 bloodstain samples collected from Bai group in Yunnan Dali region, China. The observed heterozygosity and expected heterozygosity of the 30 loci ranged from 0.1520 to 0.5680, and 0.1927 to 0.4997, respectively. No deviations from Hardy-Weinberg equilibrium tests after Bonferroni correction were found at all 30 loci in Bai group. The cumulative probability of exclusion and combined discrimination power were 0.9859 and 0.9999999999887, respectively, which indicated the 30 loci could be used as complementary genetic markers for paternity testing and were qualified for personal identification in forensic cases. We found the studied Bai group had close relationships with Tibetan, Yi and Han groups from China by the population structure, principal component analysis, population differentiations, and phylogenetic reconstruction studies. Even so, for a better understanding of Bai ethnicity’s genetic milieu, DNA genotyping at various genetic markers is necessary in future studies.

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