Oncotarget

Research Papers:

Sodium selenite prevents suppression of mucosal humoral response by AFB1 in broiler’s cecal tonsil

Chunyu Liu, Zhicai Zuo, Panpan Zhu, Zhixiang Zheng, Xi Peng, Jing Fang _, Hengmin Cui, Yi Zhou, Ping Ouyang, Yi Geng, Junliang Deng and Yu Sun

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Oncotarget. 2017; 8:54215-54226. https://doi.org/10.18632/oncotarget.17105

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Abstract

Chunyu Liu1,2,*, Zhicai Zuo1,2,*, Panpan Zhu1,2,*, Zhixiang Zheng1,2,*, Xi Peng3, Jing Fang1,2, Hengmin Cui1,2, Yi Zhou4, Ping Ouyang2, Yi Geng2, Junliang Deng1,2 and Yu Sun2

1Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, PR China

2College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, PR China

3College of Life Sciences, China West Normal University, Nanchong, Sichuan, PR China

4Life Science Department, Sichuan Agricultural University, Yaan, Sichuan, PR China

*These authors contributed equally to this work

Correspondence to:

Jing Fang, email: [email protected]

Xi Peng, email: [email protected]

Keywords: aflatoxin B1, selenium, IgA+ cell, immunoglobulin, cecal tonsil

Received: February 06, 2017     Accepted: April 02, 2017     Published: April 13, 2017

ABSTRACT

Aflatoxin B1 (AFB1), the most common mycotoxin in human food and animal feed, produces hepatotoxic, genotoxic and immunosuppressive effects in multiple species. Selenium (Se) has emerged as an important element in the dietary prevention of various toxic agents. The present study was designed to scrutinize the protective effects of sodium selenite on the histological lesions and suppression of mucosal humoral response in the cecal tonsil generated by AFB1. A total of 156 one-day-old broilers were divided into four groups and fed on basal diet (control group), 0.6 mg/kg AFB1 (AFB1 group), 0.4 mg/kg Se supplement (+Se group), and 0.6 mg/kg AFB1 + 0.4 mg/kg Se supplement (AFB1+Se group) respectively for 21 days. Our results showed that 0.4 mg/kg Se supplement in broiler’s diets could improve the AFB1-induced histological lesions in the cecal tonsils including the depletion of lymphocytes in the lymphatic nodules as well as the shedding of microvilli in the absorptive cells. Moreover, Se could restore the decreased number of IgA+ cells and expression levels of pIgR, IgA, IgG, and IgM mRNA induced by AFB1 to be close to those in the control group. These results demonstrated that 0.4 mg/kg supplemented dietary Se in the form of sodium selenite could protect the cecal tonsils from the histological lesions and suppression of the mucosal humoral response provoked by 0.6 mg/kg AFB1. Our study may provide new experimental evidences for better understanding of AFB1-induced damage of mucosal immunity and protective effect of Se against this toxin.


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