Clinical Research Papers:

Binostril endoscopic transsphenoidal neurosurgery for pituitary adenomas: experience with 42 patients

Guan Sun, Ying Cao, Nan Jiang, Dekang Nie, Zhengqiang Wan, Min Li, Chiyuan Ma and Jun Guo _

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Oncotarget. 2017; 8:69020-69024. https://doi.org/10.18632/oncotarget.16976

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Guan Sun1,*, Ying Cao2,*, Nan Jiang1, Dekang Nie1, Zhengqiang Wan1, Min Li3, Chiyuan Ma4 and Jun Guo1

1 Department of Neurosurgery, The First People’s Hospital of Yancheng, Yancheng, P R China

2 Department of Ear-Nose-Throat, The Second People’s Hospital of Huai’An, Huai’An, P R China

3 Department of Neurosurgery, Jiangning Hospital Affiliated with Nanjing Medical University, Nanjing, P R China

4 Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, P R China

* These authors have contributed equally to this work

Correspondence to:

Jun Guo, email:

Chiyuan Ma, email:

Keywords: pituitary adenomas; bilateral nostrils; sphenoid sinus; neuroendoscopy

Received: February 15, 2017 Accepted: March 16, 2017 Published: April 09, 2017


Here we review the technical aspects of our experience with the neuroendoscopic bilateral nostril (binostril) transsphenoidal approach for pituitary adenomas. A total of 42 patients were treated in our hospital from September 2013 to December 2015. Total tumor resection was completed in 31 cases, nearly full resection was achieved in 9 cases, and partial resection was achieved in 2 cases. In most cases clinical symptoms were relieved after surgery. These included 18/22 cases with visual field and vision disorders; 19/25 cases with headaches; 11/15 cases where high baseline PRL returned to normal levels; 6/7 cases where elevated blood GH returned to normal levels; and 2/3 cases where elevated blood ACTH returned to normal levels after surgery. Postoperative complications were observed in 13 patients: 8 cases of diabetes insipidus, 4 cases of cerebrospinal fluid rhinorrhea, and 1 case of subarachnoid hemorrhage. Among the key advantages of the neuroendoscopic binostril transsphenoidal approach for pituitary adenoma resection are its minimally-invasive nature, clear exposure of the operative field, high full-excision rates, improved peri-operative safety, and minor patient trauma with fewer postoperative complications.

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