Oncotarget

Research Papers:

Serrated adenocarcinoma morphology in colorectal mucinous adenocarcinoma is associated with improved patient survival

Chung-Ta Lee _, Yu-Chuan Huang, Liang-Yi Hung, Nan-Haw Chow, Pei-Fang Su, Chung-Liang Ho, Hung-Wen Tsai, Yi-Lin Chen, Shao-Chieh Lin, Bo-Wen Lin, Peng-Chan Lin and Jenq-Chang Lee

PDF  |  HTML  |  Supplementary Files  |  How to cite  |  Order a Reprint

Oncotarget. 2017; 8:35165-35175. https://doi.org/10.18632/oncotarget.16815

Metrics: PDF 1840 views  |   HTML 1607 views  |   ?  


Abstract

Chung-Ta Lee1, Yu-Chuan Huang2,*, Liang-Yi Hung2,3,*, Nan-Haw Chow1, Pei-Fang Su4, Chung-Liang Ho1, Hung-Wen Tsai1, Yi-Lin Chen1, Shao-Chieh Lin4, Bo-Wen Lin5, Peng-Chan Lin6 and Jenq-Chang Lee5

1Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan

2Institute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan

3Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan

4Department of Statistics, College of Management, National Cheng Kung University, Tainan 70101, Taiwan

5Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan

6Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan

*These authors have contributed equally to this work

Correspondence to:

Chung-Ta Lee, email: lcta@mail.ncku.edu.tw

Jenq-Chang Lee, email: leejc@mail.ncku.edu.tw

Keywords: colorectal cancer, mucinous adenocarcinoma, serrated adenocarcinoma, CIMP, BRAF

Received: December 14, 2016    Accepted: March 19, 2017    Published: April 04, 2017

ABSTRACT

Colorectal mucinous adenocarcinoma (MAC) and serrated adenocarcinoma (SAC) share many characteristics, including right-side colon location, frequent mucin production, and various molecular features. This study examined the frequency of SAC morphology in MACs. We assessed the correlation of SAC morphology with clinicopathological parameters, molecular characteristics, and patient prognosis. Eighty-eight colorectal MACs were collected and reviewed for SAC morphology according to Makinen’s criteria. We sequenced KRAS and BRAF, assessed CpG island methylator phenotype (CIMP) frequency, and analyzed DNA mismatch repair enzyme levels using immunohistochemistry in tumor samples. SAC morphology was observed in 38% of MACs, and was associated with proximal location (P=0.001), BRAF mutation (P=0.042), CIMP-positive status (P=0.023), and contiguous traditional serrated adenoma (P=0.019). Multivariate analysis revealed that MACs without both SAC morphology and CIMP-positive status exhibited 3.955 times greater risk of cancer relapse than MACs having both characteristics or either one (P=0.035). Our results show that two MAC groups with distinct features can be identified using Makinen’s criteria, and suggest a favorable prognostic role for the serrated neoplastic pathway in colorectal MAC.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 16815