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Efficacy and safety of traditional chemotherapies for patients with ovarian neoplasm: a network meta-analysis

Lili Yang, Gongliang Guo, Liqun Sun, Chenhao Li and Haipeng Zhang _

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Oncotarget. 2017; 8:59867-59877. https://doi.org/10.18632/oncotarget.16729

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Abstract

Lili Yang1, Gongliang Guo2, Liqun Sun3, Chenhao Li4 and Haipeng Zhang5

1 Department of Gynecology and Obstetrics, The First Hospital of Jilin University, Changchun, Jilin, China

2 Department of Cardiology, China Japan Union Hospital Jilin University, Changchun, Jilin, China

3 Outpatient Department of Pediatrics, The First Hospital of Jilin University, Changchun, Jilin, China

4 Department of Nephropathy, The First Hospital of Jilin University, Changchun, Jilin China

5 Department of Gynecology, The First Hospital of Jilin University, Changchun, Jilin, China

Correspondence to:

Haipeng Zhang, email:

Keywords: ovarian neoplasm, network meta-analysis, carboplatin, pegylated liposomal doxorubicin, paclitaxel

Received: January 07, 2017 Accepted: February 24, 2017 Published: March 30, 2017

Abstract

Background: Ovarian neoplasm is a kind of high risky cancer among female. This paper assessed the efficacy and safety of twelve therapies and figured out the superior chemotherapeutic drug for ovarian cancer through network meta-analysis (NMA).

Method: Eligible randomized controlled trials (RCTs) were retrieved from electronic databases. Primary outcomes concerning efficacy, overall survival (OS) and progression-free survival (PFS), were presented as hazard ratio (HR) and the associated 95% credible interval(CrI), while outcomes concerning safety were assessed by odds ratio (OR) and the corresponding 95% CrI. Surface under the cumulative ranking curve (SUCRA) was calculated under each survival and safety outcome in order to show the rankings of tested therapies.

Result: Electronic databases such as PubMed and Embase were searched to finally obtain 19 eligible studies of 16290 patients. In accordance of primary outcomes, when it came to 3-y PFS, paclitaxel/epirubicin/carboplatin (Pa/E/Ca) and pegylated liposomal doxorubicin/ paclitaxel/ carboplatin (PLD/Pa/Ca) were preferred compared to carboplatin (Ca) (HR= 0.80, 95% CrI= 0.67-0.96; HR= 0.83, 95% CrI= 0.69-0.99). According to 5y-PFS, Pa/E/Ca was notably better than Ca (HR= 0.80, 95% CrI= 0.65-0.99). As to adverse effects, Ca was superior to Pa/E/Ca in neuropathy (HR=0.05, 95% CrI=0.02-0.19). Pa/E/Ca showed high rankings in 3y-PFS (SUCRA=0.749), 5y-OS (SUCRA=0.738) and 5y-PFS (SUCRA=0.798) while (PLD/Pa/Ca) in 3y-OS (SUCRA=0.737), 5y-OS (SUCRA=0.687) and 5y-PFS (SUCRA=0.712). Besides, Pa/E/Ca ranked the third with a SUCRA of 0.661 in neutropenia.

Conclusion: PLD/Pa/Ca, PLD/Ca and Pa/E/Ca are highly recommended as potential therapeutically choices for patients with ovarian cancer. But considering the lack of safety data for PLD/Pa/Ca, this intervention should be taken with caution.


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