Meta-analysis of the association between variants in MAPT and neurodegenerative diseases
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Cheng-Cheng Zhang1, Jun-Xia Zhu2, Yu Wan3, Lin Tan4, Hui-Fu Wang2, Jin-Tai Yu3 and Lan Tan1,3,4
1 Department of Neurology, Qingdao Municipal Hospital, Dalian Medical University, Dalian, Liaoning, PR China
2 Clinical Skills Training Center, Qingdao Municipal Hospital, Qingdao University, Qingdao, Shandong, PR China
3 Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, Shandong, PR China
4 College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, Shandong, China
Lan Tan, email:
Keywords: MAPT, polymorphism, haplotype, neurodegenerative disease, meta-analysis
Received: January 05, 2017 Accepted: March 16, 2017 Published: March 29, 2017
Microtubule-associated protein tau (MAPT) gene is compelling among the susceptibility genes of neurodegenerative diseases which include Alzheimer’s disease (AD), Parkinson’s disease (PD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Our meta-analysis aimed to find the association between MAPT and the risk of these diseases. Published literatures were retrieved from MEDLINE and other databases, and 82 case-control studies were recruited. Six haplotype tagging single-nucleotide polymorphisms (rs1467967, rs242557, rs3785883, rs2471738, del-In9 and rs7521) and haplotypes (H2 and H1c) were significantly associated with the above diseases. The odds ratios (ORs) and 95 % confidence intervals (CIs) were evaluated by comparison in minor and major allele frequency using the R software. This study demonstrated that different variants in MAPT were associated with AD (rs2471738: OR= 1.04, 95%CI = 1.00 - 1.09; H2: OR = 0.94, 95% CI = 0.91 - 0.97), PD (H2: OR = 0.76, 95% CI = 0.74 - 0.79), PSP (rs242557: OR = 1. 96, 95% CI = 1. 71 - 2.25; rs2471738: OR = 1. 85, 95% CI = 1. 48 - 2.31; H2: OR = 0.20, 95% CI = 0.18 - 0.23), CBD (rs242557: OR = 2.51, 95%CI = 1. 66 -3.78; rs2471738: OR = 2.07, 95%CI = 1. 32 -3.23; H2: OR = OR = 0.30, 95% CI = 0.23 - 0.41) and ALS (H2: OR = 0.92, 95% CI = 0.86 - 0.98) instead of FTD (H2: OR = 1.02, 95% CI = 0.78 - 1.32). In conclusion, MAPT is associated with risk of neurodegenerative diseases, suggesting crucial roles of tau in neurodegenerative processes.
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