miRNA dysregulation and the risk of metastasis and invasion in papillary thyroid cancer: a systematic review and meta-analysis

Tiantian Wang, Hao Xu, Ming Qi, Xingsong Tian _ and Xingsong Tian

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Oncotarget. 2018; 9:5473-5479. https://doi.org/10.18632/oncotarget.16681

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Tiantian Wang1, Hao Xu1, Ming Qi1, Sheng Yan2 and Xingsong Tian1

1 Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China

2 Department of Neurosurgery, The First Hospital Affiliated to Sun Yat-sen University, Guangzhou, Guangdong, China

Correspondence to:

Sheng Yan, email:

Xingsong Tian, email:

Keywords: miRNA, invasive thyroid cancer, metastasis, meta-analysis

Received: November 18, 2016 Accepted: March 13, 2017 Published: March 29, 2017


Thyroid cancer (TC) is the most common endocrine malignancy, with an incidence continuing to grow every year. Although thyroid cancer as a whole is generally indolent and relatively easy to treat, some subtypes carry a higher rate of metastasis and cancer-related mortality. A growing number of studies have focused on the dysregulation of miRNAs in TC. However, differences in methods make comparison of gene profiling data difficult. A meta-analysis of published studies comparing miRNA expression data of invasive thyroid carcinoma with paired non-invasive tumors or normal tissues was performed by searching the literature for “invasion”, “thyroid cancer”, and “miRNA”. This revealed 29 dysregulated miRNAs associated with TC in 16 articles; the presence of invasion was confirmed in each respective article by laboratory research or patient follow-up. Among these miRNAs, miRNA-146b, miRNA-221, and miRNA-222 were analyzed further due to their higher frequencies across multiple studies. Of these studies, 6 were included in the meta-analysis, as they compared invasive PTC with paired normal tissues or non-invasive PTC.

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