Association of VEGF and VDR gene- gene and gene- smoking interaction on risk of multiple myeloma in Chinese Han population
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Peng Chen1, Zhen-Lan Du2,3,4, Yuan Zhang1, Bing Liu1, Zhi Guo1, Jin-Xing Lou1, Xue-Peng He1 and Hui-Ren Chen1
1Department of Hematology, PLA Army General Hospital, Beijing, 100700, People’s Republic of China
2Department of Hematology and Oncology, Affiliated Bayi Children’s Hospital, PLA Army General Hospital, Beijing, 100700, People’s Republic of China
3National Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Beijing, 100700, People’s Republic of China
4Beijing Key Laboratory of Pediatric Organ Failure, Beijing, 100700, People’s Republic of China
Hui-Ren Chen, email: email@example.com
Keywords: multiple myeloma, vascular endothelial growth factor, vitamin D receptor, smoking, interaction
Received: January 16, 2017 Accepted: February 28, 2017 Published: March 23, 2017
Aims: To investigate the association of several single nucleotide polymorphisms (SNPs) within vascular endothelial growth factor (VEGF) and vitamin D receptor (VDR) gene polymorphisms and additional gene- gene and gene- smoking interaction with multiple myeloma (MM) risk in Chinese population.
Methods: Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among SNPs and smoking. Logistic regression was performed to investigate association between 6 SNPs within VEGF and VDR gene, additional gene- gene and gene- smoking interaction on MM risk.
Results: MM risk is significantly higher in carriers with the rs699947- A allele within VEGF gene than those with CC genotype (CA+ AA versus CC), adjusted OR (95%CI) =1.72 (1.19-2.33), and higher in carriers with rs2228570- T allele within VDR gene than those with CC genotype (CT+ TT versus CC), adjusted OR (95%CI) = 1.68 (1.26-2.17). We also found a significant two-locus model (p=0.0010) involving rs699947 and rs2228570, and a significant two-locus model (p=0.0107) involving rs2228570 andsmoking. Participants with rs699947- CA+AA and rs2228570- CT+TT genotype had the highest MM risk, compared to participants with rs699947- CC and rs2228570- CC genotype, OR (95%CI) = 3.12 (1.82 -4.61). Smokers with rs2228570- CT+TT genotype had the highest MM risk, compared to never- smokers with rs2228570- CC genotype, OR (95%CI) = 3.27 (1.74-4.86).
Conclusions: We found that the A allele of rs699947 within VEGF and T allele of rs2228570 within VDR gene, interaction between rs699947 and rs2228570, rs2228570 andsmoking were all associated with increased MM risk.
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