Oncotarget

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Association between HIF1A rs11549465 polymorphism and risk of prostate cancer: a meta-analysis

Xiao-Dong Li, Hao Zi, Cheng Fang and Xian-Tao Zeng _

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Oncotarget. 2017; 8:44910-44916. https://doi.org/10.18632/oncotarget.16489

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Abstract

Xiao-Dong Li1,*, Hao Zi1,*, Cheng Fang2 and Xian-Tao Zeng1,2,3

1 Department of Urology, Center for Evidence-Based Medicine, Management Office of Scientific Research and Postgraduate Affairs, Huaihe Hospital of Henan University, Kaifeng, China

2 Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China

3 Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China

* These authors are the co-first author

Correspondence to:

Xian-Tao Zeng, email:

Keywords: HIF1A, prostate cancer, polymorphism, risk, susceptibility

Received: January 06, 2017 Accepted: March 13, 2017 Published: March 22, 2017

Abstract

The hypoxia inducible factor 1-alpha (HIF1A) gene has been suggested to play a critical role in cancer progression, and the relationship between HIF1A rs11549465 polymorphism and risk of prostate cancer has been investigated in previous studies. Nevertheless, conflicting results have been obtained. Hence, we reevaluated this issue by means of this meta-analysis, with the purpose of providing more precise conclusion on this issue. The electronic databases of PubMed, EMBASE and Chinese National Knowledge Infrastructure (CNKI) as well as other sources were searched for relevant reports concerning on the role of HIF1A rs11549465 polymorphism in the occurrence of prostate cancer. The strength of the relationship was determined by calculating odds ratios (ORs) with corresponding 95% confidence intervals (95% CIs). Besides, subgroup analyses by ethnicity and source of control were further performed to examine this relationship. All statistical analyses were performed using STATA software 12.0. Although HIF1A rs11549465 polymorphism showed a tendency of increasing the risk of prostate cancer, no statistical significance was detected under any genetic models. Similar results were also revealed in subgroup analyses on the basis of ethnicity and control source. Our findings indicate that HIF1A rs11549465 polymorphism may not independently play a significant role in the occurrence of prostate cancer.


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