Signal transduction growth factors: the effective governance of transcription and cellular adhesion in cancer invasion

Marina Di Domenico _ and Antonio Giordano

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Oncotarget. 2017; 8:36869-36884. https://doi.org/10.18632/oncotarget.16300

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Marina Di Domenico1,2,4 and Antonio Giordano3,4

1 Department of Biochemistry, Biophysics and General Pathology, University of Campania “Luigi Vanvitelli”, Naples, Italy

2 IRCCS Institute of Women’s Health Malzoni Clinic, Avellino, Italy

3 Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy

4 Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, PA, USA

Correspondence to:

Marina Di Domenico, email:

Keywords: cancer invasion, e-cadherin, phosphorylation, EGFR TGFβ, KGF

Received: December 01, 2016 Accepted: March 01, 2017 Published: March 16, 2017


Giulio Bizzozero classified the tissues concerning their capacity to self-renew during the adult life in labile, stable and permanent tissues. In 1940 Viktor Hamburger and Rita Levi Montalcini exposed the possibility to induce the growth of permanent cells thanks to a specific ligand Nerve Growth Factor (NGF). Stanley Cohen purified a protein the Epidermal Growth Factor (EGF), able to induce epidermis proliferation and to elicit precocious eye disclosure and teeth eruption, establishing the “inverse” relationships between the proliferation and differentiation. These two biological effects induced by EGF were according to EGFR signaling is involved in a large array of cellular functions such as proliferation, survival, adhesion, migration and differentiation. This review is focused on the key role of growth factors signaling and their downstream effectors in physiological and in pathological phenomena, the authors highlight the governance of Growth factors during the EMT in cancer invasion.

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