Clinical Research Papers:
Relationship of polymorphisms and haplotype in interleukin-16 and adiponectin gene with late-onset Alzheimer’s disease risk
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Honglei Yin1, Yuzhen Zhang1, Linlin Hua2, Jinfeng Li1, Zhilei Zeng2, Xiaopeng Yang2, Bin Gong1, Shuang Geng1, Yajun Liu1, Hui Zhang1, Yanqiu Liu1, Jing Zhao1 and Yunliang Wang2,1
1 Department of Neurology, PLA 148 Hospital, Zi Bo, Shandong, China
2 Department of Neurology, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
Yunliang Wang, email:
Keywords: interleukin-16; adiponectin; single nucleotide polymorphism; interaction; haplotype
Received: January 10, 2017 Accepted: February 24, 2017 Published: March 16, 2017
Aims: To investigate the impact of Interleukin-16 (IL- 16) and Adiponectin (ANP) gene single nucleotide polymorphisms (SNPs), gene- gene interactions and haplotype on late-onset Alzheimer’s disease (LOAD) risk.
Methods: Hardy-Weinberg equilibrium (HWE), haplotype and pairwise linkage disequilibrium (LD) analysis were investigated by using SNPstats (available online at http://bioinfo.iconcologia.net/SNPstats). Generalized multifactor dimensionality reduction (GMDR) was used to examine interaction among 4 SNPs, odds ratio (OR) and 95% confident interval (95%CI) were calculated by logistic regression model.
Results: LOAD risk was significantly higher in carriers of rs266729- G allele than those with CC genotype (CG+ GG versus CC), OR (95%CI) =1.61 (1.26-1.96), and higher in carriers of rs1501299- T allele, OR (95%CI) = 1.62 (1.32-2.12), lower in carriers of rs4072111- T allele, adjusted OR (95%CI) =0.65 (0.44-0.93). We also found a significant gene- gene interaction between rs266729 and rs4072111. Participants with CG or GG of rs266729 and CC of rs4072111 genotype have the highest LOAD risk, OR (95%CI) = 2.62 (1.64 -3.58). Haplotype containing the rs266729- G and rs1501299- T alleles were associated with increased LOAD risk, OR (95%CI)= 1.83 (1.32- 2.43), and haplotype containing the rs1131445- C and rs4072111- T alleles were associated with decreased LOAD risk, OR (95%CI)= 0.53 (0.18- 0.95).
Conclusions: We concluded that rs266729 and rs1501299 minor alleles were associated with increased LOAD risk, but rs4072111 minor allele was associated with decreased LOAD risk. We also found that interaction involving rs266729 and rs4072111, and haplotype combinations were associated with LOAD risk.
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