Research Papers:

Laminarin promotes anti-cancer immunity by the maturation of dendritic cells

Kyeongeun Song, Li Xu, Wei Zhang, Yun Cai, Bian Jang, Junghwan Oh and Jun-O Jin _

PDF  |  HTML  |  Supplementary Files  |  How to cite

Oncotarget. 2017; 8:38554-38567. https://doi.org/10.18632/oncotarget.16170

Metrics: PDF 2461 views  |   HTML 2854 views  |   ?  


Kyeongeun Song1,2,*, Li Xu1,*, Wei Zhang1, Yun Cai1, Bian Jang1,2,3,4, Junghwan Oh2,3,4 and Jun-O Jin1

1Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai, 201508, China

2Marine-Integrated Bionics Research Center, Pukyong National University, Busan, 48513, Korea

3Department of Biomedical Engineering and Center for Marine-Integrated Biomedical Technology (BK21 Plus), Pukyong National University, Busan, 48513, Korea

4Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering, Pukyong National University, Busan, 48513, Korea

*These authors have contributed equally to this work

Correspondence to:

Jun-O Jin, email: [email protected]

Keywords: laminarin, adjuvant, anti-cancer, dendritic cell maturation, cytotoxic lymphocyte activation

Received: December 28, 2016     Accepted: February 20, 2017     Published: March 14, 2017


This research evaluates the effects of laminarin on the maturation of dendritic cells and on the in vivo activation of anti-cancer immunity. In vivo treatment of C56BL/6 mice with laminarin increased the expression levels of co-stimulatory molecules and the production of pro-inflammatory cytokines in spleen dendritic cells. Laminarin enhanced ovalbumin antigen presentation in spleen dendritic cells and promoted the proliferation of OT-I and OT-II T cells. Laminarin also induced the maturation of dendritic cells in tumor-draining lymph nodes and protected interferon-γ and tumor necrosis factor-α and proliferation of OT-I and OT-II T cells in tumors. The combination treatment of laminarin and ovalbumin inhibited B16-ovallbumin melanoma tumor growth and its liver metastasis by antigen-specific immune activation, including cytotoxic T lymphocyte activation and interferon-γ production. Thus, these data demonstrated the potential of laminarin as a new and useful immune stimulatory molecule for use in cancer immunotherapy.

Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 16170