Research Papers: Pathology:

A polymorphism at IGF1 locus is associated with anemia

Maria Adelaide Marini, Gaia Chiara Mannino, Teresa Vanessa Fiorentino, Francesco Andreozzi, Francesco Perticone and Giorgio Sesti _

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Oncotarget. 2017; 8:32398-32406. https://doi.org/10.18632/oncotarget.16132

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Maria Adelaide Marini1,*, Gaia Chiara Mannino2,*, Teresa Vanessa Fiorentino2, Francesco Andreozzi2, Francesco Perticone2 and Giorgio Sesti2

1 Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy

2 Department of Medical and Surgical Sciences, University Magna-Græcia of Catanzaro, Catanzaro, Italy

* These authors have equally contributed as first authors to the work

Correspondence to:

Giorgio Sesti, email:

Keywords: insulin-like growth factor 1, hemoglobin, rs35767, anemia, single nucleotide polymorphism, Pathology Section

Received: January 30, 2017 Accepted: March 02, 2017 Published: March 11, 2017


In vitro and in vivo studies suggest that IGF-1 has a role in erythropoiesis. There is evidence that the rs35767 C/T polymorphism near IGF1 is associated with plasma IGF-1 levels. We investigated the effect of this polymorphism on hemoglobin (Hb) concentration and anemia. The study group comprised 3286 adult Whites. The rs35767 polymorphism was screened using a TaqMan allelic discrimination assay. The rs35767 polymorphism was not associated with age, gender, BMI, waist circumference, smoking, blood pressure, plasma glucose, HbA1c, type 2 diabetes, HOMA-IR, hsCRP, eGFR, and lipid profile. Erythrocyte sedimentation rate (ESR), fibrinogen, and fasting insulin levels were significantly lower in TT genotype carriers compared with C allele carriers. Hb concentration was significantly higher in carriers of the TT genotype compared with C allele carriers, and a lower proportion of TT carriers had anemia. As compared with TT genotype carriers, those bearing the CC genotype had a 2.4-fold higher risk of anemia (OR 2.40, 95%CI 1.19-4.82), and those with the CT genotype had a 2.0-fold higher risk of anemia (OR 2.06, 95%CI 1.04-4.11). The association remained significant when fasting insulin, eGFR, smoking, diabetes, ACE inhibitors, sartans or diuretics treatments, use of metformin and pioglitazone were added to the model, but its independence was not retained after inclusion of fibrinogen and ESR values into the model. In conclusion, rs35767 TT allele carriers exhibited significantly higher concentrations of Hb, and lower risk of anemia compared with C allele carriers supporting the idea that IGF-1 plays a role in erythropoiesis homeostasis.

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