Research Papers:

The prognostic value of histological subtype in patients with metastatic bladder cancer

Cheng Chen, Linkun Hu, Ye Chen and Jianquan Hou _

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Oncotarget. 2017; 8:28408-28417. https://doi.org/10.18632/oncotarget.16083

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Cheng Chen1,*, Linkun Hu1,*, Ye Chen1, Jianquan Hou1

1Department of Urology, the First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China

*These authors contributed equally to this work

Correspondence to:

Jianquan Hou, email: houjianquan@suda.edu.cn

Keywords: urinary bladder neoplasms, histology, distant metastasis, prognosis, survival

Received: December 14, 2016     Accepted: February 28, 2017     Published: March 10, 2017


We aim to evaluate the prognostic effect of the histological sub-type in patients with metastatic bladder cancer based on the Surveillance Epidemiology and End Results database. A total of 2634 eligible patients were included. The histological subtypes were: transitional cell carcinoma (TCC; 75.2%); adenocarcinoma (3.3%); squamous cell carcinoma (SQCC; 4.1%); and small cell carcinoma (4.3%). A significant association of adenocarcinoma with better survival outcomes (P < 0.015), and that of SQCC with worse outcomes (P < 0.001) was observed. On multivariate analysis, adenocarcinoma was significantly associated with longer and SQCC with shorter survival time as compared to TCC. Overall, 1331 (50.5%) patients had a single metastatic site and 523 (19.9%) had multiple sites involved. Single-site metastasis had a better survival outcome than multiple metastases (P < 0.001). Histological sub-type and presence of multiple metastatic sites are independent predictors of survival time. Prospective, in-depth research is needed to determine optimal therapeutic strategies for different histological subtypes of bladder cancer with different metastatic patterns.

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