Oncotarget

Research Papers:

Effect of radiotherapy after breast-conserving surgery in older patients with early breast cancer and breast ductal carcinoma in situ: a meta-analysis

Xuan-zhang Huang, You Chen, Wen-jun Chen, Xi Zhang, Cong-cong Wu, Chao-ying Zhang, Shuang-shuang Sun and Jian Wu _

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Oncotarget. 2017; 8:28215-28225. https://doi.org/10.18632/oncotarget.15998

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Abstract

Xuan-zhang Huang1,*, You Chen2,*, Wen-jun Chen1, Xi Zhang1, Cong-cong Wu1, Chao-ying Zhang1, Shuang-shuang Sun1, Jian Wu1

1 Department of Chemotherapy and Radiotherapy, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou City 325027, P.R. China

2 The Wenzhou Dental Hospital, Wenzhou City 325027, P.R. China

*These authors contributed equally to this work

Correspondence to:

Jian Wu, email: wzzjian1@163.com.

Keywords: radiotherapy, breast-conserving surgery, older, early breast cancer, breast ductal carcinoma in situ

Received: October 22, 2016     Accepted: February 28, 2017     Published: March 08, 2017

ABSTRACT

Background: There are no consistent agreements on whether radiotherapy after breast-conserving surgery (BCS) could provide local control and survival benefit for older patients with early breast cancer or breast ductal carcinoma in situ (DCIS). The present study aimed to evaluate the efficacy of radiotherapy after BCS in older patients with early breast cancer or DCIS.

Results: Radiotherapy could reduce the risk of local relapse in older patients with early breast cancer. The 5-year AR of local relapse was 2.2% and 6.2% for radiotherapy and non-radiotherapy group, respectively, with low 5-year ARD of 4.0% and high NNT of 25. The 10-year AR of local relapse was 5.3% and 10.5% for radiotherapy and non-radiotherapy group, respectively, with the 10-year ARD of 5.2% and NNT of 20. However, radiotherapy could not improve survival benefits, including overall survival, cancer-specific survival, breast-cancer-specific survival, and distant relapse. Moreover, radiotherapy could reduce the risk of ipsilateral breast events in older patients with DCIS.

Materials and Methods: PubMed and Embase database were searched for relevant studies. Hazard ratios (HRs), risk ratios (RRs), absolute risk (AR), absolute risk difference (ARD), and number needed to treat (NNT) were used as effect measures to evaluate the efficacy of radiotherapy in older patients.

Conclusions: Our study indicates that radiotherapy could slightly reduce the risk of local relapse in older patients with favorable early breast cancer. However, radiotherapy cannot translate into significant survival benefits.


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PII: 15998