Oncotarget

Research Papers:

Ceruloplasmin as a prognostic marker in patients with bile duct cancer

In Woong Han, Jin-Young Jang _, Wooil Kwon, Taesung Park, Yongkang Kim, Kyoung Bun Lee and Sun-Whe Kim

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Oncotarget. 2017; 8:29028-29037. https://doi.org/10.18632/oncotarget.15995

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Abstract

In Woong Han1,2, Jin-Young Jang2, Wooil Kwon2, Taesung Park3, Yongkang Kim3, Kyoung Bun Lee4, Sun-Whe Kim2

1Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-Gu, Seoul 06351, Korea

2Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Chongno-Gu, Seoul 110-744, Korea

3Department of Statistics, Seoul National University College of Natural Sciences, Gwanak-Gu, Seoul 08826, Korea

4Department of Pathology, Seoul National University College of Medicine, Chongno-Gu, Seoul 110-744, Korea

Correspondence to:

Jin-Young Jang, email: jangjy4@snu.ac.kr

Keywords: bile duct, cancer, cholangiocarcinoma, biomarker, ceruloplasmin

Received: November 09, 2016    Accepted: February 06, 2017    Published: March 07, 2017

ABSTRACT

Background and Aims: Bile duct cancer is one of the lethal cancers, presenting difficulties in early diagnosis and limited treatment modalities. Despite current advances in biomarker research, most studies have been performed in Western populations. Therefore, the purpose of this study was to determine a prognostic marker for bile duct cancer, especially in Korean patients, whose incidence of bile duct cancer is high.

Results: Comparing cancer and normal bile duct tissue, we identified 29091 differentially expressed genes. CP, SCEL, and MUC16 had positive coefficients with a log2 ratio >1 for advanced T, N stage and perineural invasion cancer tissue. Strong immunohistochemical expression of ceruloplasmin was dominant in tumors with advanced T stage (p>0.999) and perineural invasion (p=0.316).

Patients and Methods: We performed tissue microarray experiment with 79 bile duct cancer tissue samples and 21 normal bile duct tissue samples. Candidate genes that has positive correlation with T, N stage and perineural invasion were drawn with multivariate analysis. Tissue expression of the genes was evaluated with an immunohistochemical study.

Conclusions: Ceruloplasmin is supposed to be related with advanced T stage and perineural invasion, having a possibility as a candidate prognostic marker for bile duct cancer.


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