Oncotarget

Research Papers:

Low forced vital capacity predicts poor prognosis in gastric cancer patients

Fan Feng, Yangzi Tian, Yuan Zang, Li Sun, Liu Hong, Jianjun Yang, Man Guo, Xiao Lian, Daiming Fan and Hongwei Zhang _

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Oncotarget. 2017; 8:28897-28905. https://doi.org/10.18632/oncotarget.15953

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Abstract

Fan Feng1,*, Yangzi Tian2,*, Yuan Zang3,*, Li Sun1, Liu Hong1, Jianjun Yang1, Man Guo1, Xiao Lian1, Daiming Fan1, Hongwei Zhang1

1Division of Digestive Surgery, Xijing Hospital of Digestive Disease, Fourth Military Medical University, 710032, Xi’an, Shaanxi, China

2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, 710032, Xi’an, Shaanxi, China

3Department of Orthopedics, Xijing Hospital, Fourth Military Medical University, 710032, Xi’an, Shaanxi, China

*These authors have contributed equally to this work

Correspondence to:

Hongwei Zhang, email: zhanghwfmmu@126.com

Keywords: gastric cancer, forced vital capacity, maximal voluntary ventilation, postoperative complications, prognosis

Received: August 17, 2016     Accepted: February 14, 2017     Published: March 07, 2017

ABSTRACT

Preoperative pulmonary function assessment is used to select surgical candidates and predict the occurrence of postoperative complications. The present study enrolled 1210 gastric cancer patients (949 males and 261 females). Forced vital capacity (FVC) and maximal voluntary ventilation (MVV) were measured as a percent of predicted values. We then analyzed associations between patient pulmonary function and both prognosis and postoperative complications. Patient 1-, 3- and 5-year overall survival rates were 88.8%, 65.7% and 53.0%, respectively. FVC and MVV optimal cutoff values were 87.0 (P=0.003) and 83.6 (P=0.026), respectively. Low FVC and low MVV were associated with higher rates of postoperative fever (23.8% vs. 13.9%, P<0.001; 17.8% vs. 13.3%, P=0.049, respectively) and poor patient prognosis (5-year overall survival: 43.5% vs. 57.6%, P=0.003; 51.8% vs. 54.3%, P=0.026, respectively). Only low FVC was an independent prognostic predictor for gastric cancer (P=0.012). In subgroup analyses, FVC was not associated with stage I or II gastric cancer patient prognoses (P>0.05), but low FVC was an independent risk factor for poor prognosis in stage III gastric cancer cases (P=0.004). These findings indicate that low FVC is predictive of poorer prognosis and higher risk of postoperative fever in gastric cancer patients.


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