Oncotarget

Research Papers:

Combined effects of glutathione S-transferase M1 and T1 polymorphisms on risk of lung cancer: evidence from a meta-analysis

Ying Gao _, Fei Gao, Ting-Ting Hu, Gang Li and Yan-Xia Sui

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Oncotarget. 2017; 8:28135-28143. https://doi.org/10.18632/oncotarget.15943

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Abstract

Ying Gao1,*, Fei Gao2,*, Ting-Ting Hu3, Gang Li4, Yan-Xia Sui5

1Department of Radiotherapy Oncology, First Affiliated Hospital of Medical College of Xi’an, Jiao Tong University, Xi’an, Shanxi, China

2Department of Neurology, First Affiliated Hospital of Xi’an Medical University, Xi’an, Shanxi, China

3Department of Medical, First Affiliated Hospital of Medical College of Xi’an, Jiao Tong University, Xi’an, Shanxi, China

4Second Department of Thoracic Surgery, First Affiliated Hospital of Medical College of Xi’an, Jiao Tong University, Xi’an, Shanxi, China

5Department of Pathology, First Affiliated Hospital of Medical College of Xi’an, Jiao Tong University, Xi’an, Shanxi, China

*These authors contributed equally to this work and should be considered as co-first authors

Correspondence to:

Ying Gao, email: gaoyyingqw@163.com, togaoying@163.com

Keywords: GSTM1, GSTT1, polymorphism, lung cancer, meta-analysis

Received: September 14, 2016     Accepted: February 23, 2017     Published: March 06, 2017

ABSTRACT

Many studies have reported an association between the glutathione S-transferase M1 null and T1 null polymorphisms and lung cancer risk. However, the combined effects of GSTM1 null and GSTT1 null polymorphisms have not been reported previously. We, therefore, performed a meta-analysis to investigate the combined effects. 40 publications with 44 case–control studies were selected in the meta-analysis, including 13,706 cases and 13,093 controls. Significant association was observed between the combined effects of GSTM1 and GSTT1 polymorphisms and lung cancer risk when all the eligible studies were pooled into the meta-analysis. When we performed subgroup analysis, significantly increased lung cancer risk was observed in Caucasians (− − vs. + + : OR = 1.23, 95% CI: 1.07 to 1.41), Asians (− − vs.− +: OR = 1.24, 95% CI: 1.10 to 1.41; recessive model: OR = 1.45, 95% CI: 1.19 to 1.77; dominant model: OR = 1.53, 95% CI: 1.24 to 1.90), Indians (− − vs. + + : OR = 2.53, 95% CI: 1.61 to 3.98; recessive model: OR = 1.69, 95% CI: 1.07 to 2.67; dominant model: OR = 2.11, 95% CI: 1.36 to 3.28), hospital-based studies, and population-based studies. In summary, this meta-analysis indicates that the combined effects of the GSTM1 and GSTT1 polymorphisms are associated with increased lung cancer risk in Asians, Caucasians, and Indians.


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