ROR1 expression as a biomarker for predicting prognosis in patients with colorectal cancer
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Jian-Kang Zhou1,*, Yu-Zhu Zheng2,3,*, Xue-Sha Liu1, Qiheng Gou1, Rui Ma1, Cheng-Lin Guo1, Carlo M. Croce4, Lunxu Liu1 and Yong Peng1
1Department of Thoracic Surgery and Lab of Non-coding RNAs in Diseases, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, China
2Department of Thoracic Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
3Department of Oncology, The Third People’s Hospital of Chengdu, Chengdu, Sichuan, China
4Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA
*These authors have contributed equally to this work
Yong Peng, email: [email protected]
Lunxu Liu, email: [email protected]
Keywords: receptor-tyrosine-kinase-like orphan receptor 1, colorectal cancer, prognostic factor, tissue microarray, immunohistochemistry
Received: November 30, 2016 Accepted: February 07, 2017 Published: March 02, 2017
There is a lack of reliable prognosis biomarker in the current treatment of colorectal cancer. The receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is overexpressed and associated with poor prognosis in certain tumors. This study aimed to explore the prognostic significance of ROR1 in colorectal cancer. Western blot analysis and immunohistochemistry showed that the expression of ROR1 in colorectal cancer was significantly higher than that in the adjacent normal tissues. ROR1 expression was positively associated with the clinical stage and lymph-node metastasis (p < 0.01). Kaplan-Meier survival analysis revealed that patients with higher ROR1 expression had a significantly shorter overall survival (p < 0.01). Multivariate Cox regression analysis confirmed that ROR1 is an independent prognostic marker in colorectal cancer (p = 0.002, HR = 2.08, 95% CI: 1.314–3.292). Thus, our study demonstrated that ROR1 expression is correlated with malignant attributes and may serve as a novel prognostic marker and therapeutic target for colorectal cancer.
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